Journal article
Selection and fading of resistance mutations in women and infants receiving nevirapine to prevent HIV-1 vertical transmission (HIVNET 012)
AIDS (London), Vol.15(15), pp.1951-1957
10/2001
DOI: 10.1097/00002030-200110190-00006
PMID: 11600822
Abstract
Objective: To examine the emergence and fading of NVP resistance (NVP(R)) mutations in HIV-1-infected Ugandan women and infants who received single dose NVP to prevent HIV-1 vertical transmission.
Design: We examined NVP(R) in women and infants who received NVP in the HIVNET 012 clinical trial, including 41 out of 48 women with infected infants, 70 randomly-selected women with uninfected infants, and 33 out of 49 infected infants.
Methods: Plasma HIV-1 was analyzed using the Applied Biosystems ViroSeq HIV-1 Genotyping System.
Results: NVP(R) mutations were detected in 21 out of 111 (19%) women tested 6-8 weeks after delivery. The rate of NVP(R) was similar among women whose infants were or were not HIV-1 infected. K103N was the most common mutation detected. NVP(R) mutations faded from detection within 12-24 months in all 11 evaluable women. High baseline viral load and low baseline CD4 cell count were associated with development of NVP(R). NVP(R) mutations were detected in 11 out of 24 (46%) evaluable infants who were infected by 6-8 weeks of age. The most common NVP(R) mutation detected in infants was Y181C. Those mutations faded from detection by 12 months of age in all seven evaluable infants. Of nine evaluable infants with late HIV-1 infection, only one had evidence of NVP(R).
Conclusions: NVP(R) was detected more frequently in infants than women following NVP prophylaxis, and different patterns of NVP(R) mutations were detected in women versus infants. NVP(R) was detected infrequently in infants with late HIV-1 infection. NVP-resistant HIV-1 faded from detection in women and infants over time.
Details
- Title: Subtitle
- Selection and fading of resistance mutations in women and infants receiving nevirapine to prevent HIV-1 vertical transmission (HIVNET 012)
- Creators
- Susan H EshlemanMartin MracnaLaura A GuayMartina DeseyveShawn CunninghamMark MirochnickPhilippa MusokeThomas FlemingMary Glenn FowlerLynne M MofensonFrancis MmiroJ. Brooks Jackson
- Resource Type
- Journal article
- Publication Details
- AIDS (London), Vol.15(15), pp.1951-1957
- DOI
- 10.1097/00002030-200110190-00006
- PMID
- 11600822
- ISSN
- 0269-9370
- eISSN
- 1473-5571
- Language
- English
- Date published
- 10/2001
- Academic Unit
- Pathology; VPMA - Administration
- Record Identifier
- 9984046919302771
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