Journal article
Selection bias at the heterosexual HIV-1 transmission bottleneck
Science (American Association for the Advancement of Science), Vol.345(6193), pp.178-178
07/11/2014
DOI: 10.1126/science.1254031
PMCID: PMC4289910
PMID: 25013080
Abstract
Heterosexual transmission of HIV-1 typically results in one genetic variant establishing systemic infection. We compared, for 137 linked transmission pairs, the amino acid sequences encoded by non-envelope genes of viruses in both partners and demonstrate a selection bias for transmission of residues that are predicted to confer increased in vivo fitness on viruses in the newly infected, immunologically naive recipient. Although tempered by transmission risk factors, such as donor viral load, genital inflammation, and recipient gender, this selection bias provides an overall transmission advantage for viral quasispecies that are dominated by viruses with high in vivo fitness. Thus, preventative or therapeutic approaches that even marginally reduce viral fitness may lower the overall transmission rates and offer long-term benefits even upon successful transmission.
Details
- Title: Subtitle
- Selection bias at the heterosexual HIV-1 transmission bottleneck
- Creators
- Jonathan M. Carlson - Microsoft (United States)Malinda Schaefer - Emory UniversityDaniela C. Monaco - Emory UniversityRebecca Batorsky - Ragon Institute of MGH, MIT and HarvardDaniel T. Claiborne - Emory UniversityJessica Prince - Emory UniversityMartin J. Deymier - Emory UniversityZachary S. Ende - Emory UniversityNichole R. Klatt - Emory UniversityCharles E. DeZiel - Microsoft (United States)Tien-Ho Lin - Microsoft (United States)Jian Peng - Microsoft (United States)Aaron M. Seese - Ragon Institute of MGH, MIT and HarvardRoger Shapiro - Beth Israel Deaconess Medical CenterJohn Frater - University of OxfordThumbi Ndung'u - Ragon Inst Massachusetts Gen Hosp Massachusetts I, Cambridge, MA 02114 USAJianming Tang - University of Alabama at BirminghamPaul Goepfert - University of Alabama at BirminghamJill Gilmour - International HIV/AIDS AllianceMatt A. Price - Int AIDS Vaccine Initiat, San Francisco, CA 94105 USAWilliam Kilembe - Rwanda Zambia HIV Research GroupDavid Heckerman - Microsoft (United States)Philip J. R. Goulder - University of KwaZulu-NatalTodd M. Allen - Emory UniversitySusan Allen - International AIDS Vaccine InitiativeEric Hunter - Emory University
- Resource Type
- Journal article
- Publication Details
- Science (American Association for the Advancement of Science), Vol.345(6193), pp.178-178
- DOI
- 10.1126/science.1254031
- PMID
- 25013080
- PMCID
- PMC4289910
- NLM abbreviation
- Science
- ISSN
- 0036-8075
- eISSN
- 1095-9203
- Publisher
- Amer Assoc Advancement Science
- Number of pages
- 14
- Grant note
- T32-AI007387 / Multidisciplinary AIDS Training Grant NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Victor Daitz Foundation P51OD11132 / Office of Research Infrastructure Programs/OD South African Department of Science and Technology Howard Hughes Medical Institute P01-AI074415; U01 AI 66454 / NIAID; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID) 2P51RR000165-51; P51RR165 / Yerkes National Primate Research Center through the National Center for Research Resources National Research Foundation through the South Africa Research Chairs Initiative G108/626 / Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) International AIDS Vaccine Initiative P30 AI050409 / Virology Core at the Emory Center for AIDS Research G108/626 / MRC; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) American people through the U.S. Agency for International Development (USAID); United States Agency for International Development (USAID) Action Cycling Fellowships
- Language
- English
- Date published
- 07/11/2014
- Academic Unit
- Obstetrics and Gynecology
- Record Identifier
- 9984697044302771
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