Journal article
Selective Depletion of V β-Bearing T Cells in Patients with Severe Invasive Group a Streptococcal Infections and Streptococcal Toxic Shock Syndrome
The Journal of infectious diseases, Vol.171(1), pp.74-84
01/01/1995
DOI: 10.1093/infdis/171.1.74
PMID: 7798684
Abstract
The V β repertoire of T cells of patients with gram-positive group A streptococcal (GAS) and non-GAS infections was analyzed to seek evidence for the role of superantigens in streptococcal toxic shock syndrome. No evidence of V β overexpression but a consistent pattern of depletion of Vβ1, Vβ5.1, and Vβ12 was observed in patients with severe GAS infections. This pattern of Vβ depletion was not observed in patients with nonsevere GAS infections or with severe non-GAS gram-positive infections. T cells from patients with severe GAS infections showed evidence of apoptosis; no apoptosis was found when there was no evidence of V β depletion. There was no correlation with streptococcal M or T serotype or known spe genes. The depletion of specific V β-bearing T cells in patients with severe GAS infections supports the role of a superantigen in these infections. The in vivo pattern of V β specificity implicates a novel superantigen(s) in this disease.
Details
- Title: Subtitle
- Selective Depletion of V β-Bearing T Cells in Patients with Severe Invasive Group a Streptococcal Infections and Streptococcal Toxic Shock Syndrome
- Creators
- Rika Watanabe-OhnishiDonald E. LowAllison McGeerDennis L. StevensPatrick M. SchlievertDuane NewtonBenjamin SchwartzBarry KreiswirthMalak Kotb
- Resource Type
- Journal article
- Publication Details
- The Journal of infectious diseases, Vol.171(1), pp.74-84
- DOI
- 10.1093/infdis/171.1.74
- PMID
- 7798684
- NLM abbreviation
- J Infect Dis
- ISSN
- 0022-1899
- eISSN
- 1537-6613
- Publisher
- University of Chicago Press
- Language
- English
- Date published
- 01/01/1995
- Academic Unit
- Microbiology and Immunology; Internal Medicine
- Record Identifier
- 9984001123502771
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