Journal article
Selective Developmental Increase in the Climbing Fiber Input to the Cerebellar Interpositus Nucleus in Rats
Behavioral neuroscience, Vol.118(5), pp.1111-1116
10/2004
DOI: 10.1037/0735-7044.118.5.1111
PMCID: PMC2546608
PMID: 15506893
Abstract
Previous studies have demonstrated that learning-related cerebellar plasticity and stimulus-elicited neuronal activity emerge ontogenetically in parallel with delay eyeblink conditioning in rats. The present study examined cerebellar interpositus field potentials and multiunit neuronal activity evoked by microstimulation of the inferior olive in Postnatal Day 17 and 24 rats. The slope and amplitude of the excitatory postsynaptic potential and the number of evoked multiunit spikes increased with age, whereas the inhibitory postsynaptic potential caused by Purkinje cell input remained stable. These results are consistent with the notion that the postsynaptic depolarization of cerebellar interpositus neurons caused by cerebellar afferents (e.g., the climbing fibers of the inferior olive) is a critical factor contributing to the ontogeny of delay eyeblink conditioning in rats.
Details
- Title: Subtitle
- Selective Developmental Increase in the Climbing Fiber Input to the Cerebellar Interpositus Nucleus in Rats
- Creators
- Daniel A Nicholson - Department of Psychology, University of IowaJohn H Freeman - Department of Psychology, University of Iowa
- Resource Type
- Journal article
- Publication Details
- Behavioral neuroscience, Vol.118(5), pp.1111-1116
- DOI
- 10.1037/0735-7044.118.5.1111
- PMID
- 15506893
- PMCID
- PMC2546608
- NLM abbreviation
- Behav Neurosci
- ISSN
- 0735-7044
- eISSN
- 1939-0084
- Publisher
- American Psychological Association
- Language
- English
- Date published
- 10/2004
- Academic Unit
- Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984065858502771
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