Selective Lanthanide Sensing with Gold Nanoparticles and Hydroxypyridinone Chelators

Roger M Pallares; Korey P Carter; Steven E Zeltmann; Toni Tratnjek; Andrew M Minor; Rebecca J Abergel

doi:10.1021/acs.inorgchem.9b03393

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Selective Lanthanide Sensing with Gold Nanoparticles and Hydroxypyridinone Chelators

Journal article

Peer reviewed

Selective Lanthanide Sensing with Gold Nanoparticles and Hydroxypyridinone Chelators

Roger M Pallares, Korey P Carter, Steven E Zeltmann, Toni Tratnjek, Andrew M Minor and Rebecca J Abergel

Inorganic chemistry, Vol.59(3), pp.2030-2036

02/03/2020

DOI: 10.1021/acs.inorgchem.9b03393

PMID: 31971379

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https://www.osti.gov/biblio/1631627View

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Abstract

The octadentate hydroxypyridinone chelator 3,4,3-LI(1,2-HOPO) is a promising therapeutic agent because of its high affinity for f-block elements and noncytotoxicity at medical dosages. The interaction between 3,4,3-LI(1,2-HOPO) and other biomedically relevant metals such as gold, however, has not been explored. Gold nanoparticles functionalized with chelators have demonstrated great potential in theranostics, yet thus far, no protocol that combines 3,4,3-LI(1,2-HOPO) and colloidal gold has been developed. Here, we characterize the solution thermodynamic properties of the complexes formed between 3,4,3-LI(1,2-HOPO) and Au3+ ions and demonstrate how under specific pH conditions the chelator promotes the growth of gold nanoparticles, acting as both reducing and stabilizing agent. 3,4,3-LI(1,2-HOPO) ligands on the nanoparticle surface remain active and selective toward f-block elements, as evidenced by gold nanoparticle selective aggregation. Finally, a new colorimetric assay capable of reaching the detection levels necessary for the quantification of lanthanides in waste from industrial processes is developed based on the inhibition of particle growth by lanthanides.

Details

Title: Subtitle: Selective Lanthanide Sensing with Gold Nanoparticles and Hydroxypyridinone Chelators
Creators: Roger M Pallares - Chemical Sciences Division
Korey P Carter - Chemical Sciences Division
Steven E Zeltmann - National Center for Electron Microscopy, Molecular Foundry
Toni Tratnjek - Chemical Sciences Division
Andrew M Minor - University of California
Rebecca J Abergel - University of California
Resource Type: Journal article
Publication Details: Inorganic chemistry, Vol.59(3), pp.2030-2036
DOI: 10.1021/acs.inorgchem.9b03393
PMID: 31971379
NLM abbreviation: Inorg Chem
ISSN: 0020-1669
eISSN: 1520-510X
Publisher: American Chemical Society
Grant note: name: National Science Foundation
Language: English
Date published: 02/03/2020
Academic Unit: Chemistry
Record Identifier: 9984216702102771

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