Selective Long-term Reorganization of the Corticospinal Projection from the Supplementary Motor Cortex following Recovery from Lateral Motor Cortex Injury

David W McNeal; Warren G Darling; Jizhi Ge; Kimberly S Stilwell-Morecraft; Kathryn M Solon; Stephanie M Hynes; Marc A Pizzimenti; Diane Rotella; Tyler Vanadurongvan; Robert J Morecraft

doi:10.1002/cne.22218

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Selective Long-term Reorganization of the Corticospinal Projection from the Supplementary Motor Cortex following Recovery from Lateral Motor Cortex Injury

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Selective Long-term Reorganization of the Corticospinal Projection from the Supplementary Motor Cortex following Recovery from Lateral Motor Cortex Injury

David W McNeal, Warren G Darling, Jizhi Ge, Kimberly S Stilwell-Morecraft, Kathryn M Solon, Stephanie M Hynes, Marc A Pizzimenti, Diane Rotella, Tyler Vanadurongvan and Robert J Morecraft

Journal of comparative neurology (1911), Vol.518(5), pp.586-621

03/01/2010

DOI: 10.1002/cne.22218

PMCID: PMC3765018

PMID: 20034062

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https://www.ncbi.nlm.nih.gov/pmc/articles/3765018View

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Abstract

Brain injury affecting the frontal motor cortex or its descending axons often causes contralateral upper extremity paresis. Although recovery is variable, the underlying mechanisms supporting favorable motor recovery remain unclear. Since the medial wall of the cerebral hemisphere is often spared following brain injury and recent functional neuroimaging studies in patients indicate a potential role for this brain region in the recovery process, we investigated the long-term effects of isolated lateral frontal motor cortical injury on the corticospinal projection (CSP) from intact, ipsilesional supplementary motor cortex (M2). Following injury to the arm region of the primary motor (M1) and lateral premotor (LPMC) cortices, upper extremity recovery is accompanied by terminal axon plasticity in the contralateral CSP but not the ipsilateral CSP from M2. Furthermore, significant contralateral plasticity occurs only in lamina VII and dorsally within lamina IX. Thus, selective intraspinal sprouting transpires in regions containing interneurons, flexor-related motor neurons and motor neurons supplying intrinsic hand muscles which all play important roles in mediating reaching and digit movements. Following recovery, subsequent injury of M2 leads to reemergence of hand motor deficits. Considering the importance of the CSP in humans and the common occurrence of lateral frontal cortex injury, these findings suggest that spared supplementary motor cortex may serve as an important therapeutic target that should be considered when designing acute and long-term post-injury patient intervention strategies aimed to enhance the motor recovery process following lateral cortical trauma.

Corticofugal

Frontal Lobe

Neurosurgical Resection

Plasticity

Pyramidal Tract

Spinal Cord

Details

Title: Subtitle: Selective Long-term Reorganization of the Corticospinal Projection from the Supplementary Motor Cortex following Recovery from Lateral Motor Cortex Injury
Creators: David W McNeal - University of South Dakota
Warren G Darling - University of Iowa
Jizhi Ge - University of South Dakota
Kimberly S Stilwell-Morecraft - University of South Dakota
Kathryn M Solon - University of South Dakota
Stephanie M Hynes - University of Iowa
Marc A Pizzimenti - University of Iowa
Diane Rotella - University of Iowa
Tyler Vanadurongvan - University of South Dakota
Robert J Morecraft - University of South Dakota
Resource Type: Journal article
Publication Details: Journal of comparative neurology (1911), Vol.518(5), pp.586-621
DOI: 10.1002/cne.22218
PMID: 20034062
PMCID: PMC3765018
NLM abbreviation: J Comp Neurol
ISSN: 0021-9967
eISSN: 1096-9861
Grant note: R01 NS046367 || NS / National Institute of Neurological Disorders and Stroke : NINDS
Language: English
Date published: 03/01/2010
Academic Unit: Anatomy and Cell Biology; Physical Therapy and Rehabilitation Science; Health, Sport, and Human Physiology
Record Identifier: 9984259651102771

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