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Selective N-Sulfation of Glucosamine Derivatives using Phenyl Chlorosulfate in Non-Aqueous Solvent
Journal article   Peer reviewed

Selective N-Sulfation of Glucosamine Derivatives using Phenyl Chlorosulfate in Non-Aqueous Solvent

Robert J. Kerns and Robert J. Linhardt
Synthetic communications, Vol.26(14), pp.2671-2680
07/01/1996
DOI: 10.1080/00397919608004583

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Abstract

The selective N-sulfation of 2-amino-2-deoxy-D-glucopyranose derivatives having unprotected hydroxyl groups with phenyl chlorosulfate and triethylamine in anhydrous organic solvent followed by addition of aqueous sodium bicarbonate affords high yields of the 2-deoxy-2-sulfoamino-D-glucopyranose products.

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