Journal article
Selective degeneration of synapses in the dorsal cochlear nucleus of chinchilla following acoustic trauma and effects of antioxidant treatment
Hearing research, Vol.283(1-2), pp.1-13
01/01/2012
DOI: 10.1016/j.heares.2011.11.013
PMID: 22178982
Abstract
The purpose of this study was to reveal synaptic plasticity within the dorsal cochlear nucleus (DCN) as a result of noise trauma and to determine whether effective antioxidant protection to the cochlea can also impact plasticity changes in the DCN. Expression of synapse activity markers (synaptophysin and precerebellin) and ultrastructure of synapses were examined in the DCN of chinchilla 10 days after a 105 dB SPL octave-band noise (centered at 4 kHz, 6 h) exposure. One group of chinchilla was treated with a combination of antioxidants (4-hydroxy phenyl N-tert-butylnitrone, N-acetyl-L-cysteine and acetyl-L-carnitine) beginning 4 h after noise exposure. Down-regulated synaptophysin and precerebellin expression, as well as selective degeneration of nerve terminals surrounding cartwheel cells and their primary dendrites were found in the fusiform soma layer in the middle region of the DCN of the noise exposure group. Antioxidant treatment significantly reduced synaptic plasticity changes surrounding cartwheel cells. Results of this study provide further evidence of acoustic trauma-induced neural plasticity in the DCN and suggest that loss of input to cartwheel cells may be an important factor contributing to the emergence of hyperactivity in the DCN after noise exposure. Results further suggest that early antioxidant treatment for acoustic trauma not only rescues cochlear hair cells, but also has impact on central auditory structures. (C) 2011 Elsevier B.V. All rights reserved.
Details
- Title: Subtitle
- Selective degeneration of synapses in the dorsal cochlear nucleus of chinchilla following acoustic trauma and effects of antioxidant treatment
- Creators
- Xiaoping Du - Hough Ear InstituteKejian Chen - Hough Ear InstituteChul-Hee Choi - Hough Ear InstituteWei Li - Hough Ear InstituteWeihua Cheng - Hough Ear InstituteCharles Stewart - Oklahoma Medical Research FoundationNing Hu - Hough Ear InstituteRobert A. Floyd - Oklahoma Medical Research FoundationRichard D. Kopke - Hough Ear Institute
- Resource Type
- Journal article
- Publication Details
- Hearing research, Vol.283(1-2), pp.1-13
- Publisher
- Elsevier
- DOI
- 10.1016/j.heares.2011.11.013
- PMID
- 22178982
- ISSN
- 0378-5955
- eISSN
- 1878-5891
- Number of pages
- 13
- Grant note
- Office of Naval Research (ONR) and Integris Health, Oklahoma City, Oklahoma
- Language
- English
- Date published
- 01/01/2012
- Academic Unit
- Anatomy and Cell Biology; Biology
- Record Identifier
- 9984627307502771
Metrics
10 Record Views