Journal article
Selective induction of bilirubin UDP-glucuronosyl-transferase by perfluorodecanoic acid
Chemico-biological interactions, Vol.77(1), pp.97-105
1991
DOI: 10.1016/0009-2797(91)90008-U
PMID: 1898504
Abstract
Differential effects of perfluorodecanoic acid (PFDA) on rat liver UDP-glucuronosyltransferase isoenzymes have been observed after a single i.p. administration of the compound to young male Sprague-Dawley rats. (1) Bilirubin glucuronidation was induced 2-fold. The induced state was stable for at least 3 weeks. (2) Glucuronidation of 1-naphthol, morphine and testosterone was decreased to half of the control values. These decreases were maximal after 12 days but all three activities returned to normal levels after 3 weeks. (3) Immunoblotting experiments indicated that the differential effects of PFDA on UDP-glucuronosyltransferase activities were due to modulation of enzyme protein concentrations rather than activation/inactivation mechanisms. With respect to its influence on UDP-glucuronosyltransferase isoenzymes, PFDA may be classified as a clofibrate-type inducer. The persistence of the induction after a single application however is unique among peroxisome proliferators and therefore PFDA may be a useful, elective inducer of bilirubin glucuronidation.
Details
- Title: Subtitle
- Selective induction of bilirubin UDP-glucuronosyl-transferase by perfluorodecanoic acid
- Creators
- M Arand - Institute of Toxicology, University of Mainz, F.R.GM W CoughtrieB BurchellF OeschL W Robertson
- Resource Type
- Journal article
- Publication Details
- Chemico-biological interactions, Vol.77(1), pp.97-105
- Publisher
- Ireland
- DOI
- 10.1016/0009-2797(91)90008-U
- PMID
- 1898504
- ISSN
- 0009-2797
- eISSN
- 1872-7786
- Grant note
- Wellcome Trust
- Language
- English
- Date published
- 1991
- Academic Unit
- Occupational and Environmental Health
- Record Identifier
- 9984002598202771
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