Selective infection of human CD4+ cells by simian immunodeficiency virus: productive infection associated with envelope glycoprotein-induced fusion

Scott Koenig; Vanessa M Hirsch; Robert A Olmsted; Douglas Powell; Wendy Maury; Arnold  Rabson; Anthony S Fauci; Robert H Purcell; Philip R Johnson

doi:10.1073/pnas.86.7.2443

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Selective infection of human CD4+ cells by simian immunodeficiency virus: productive infection associated with envelope glycoprotein-induced fusion

Journal article

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Selective infection of human CD4+ cells by simian immunodeficiency virus: productive infection associated with envelope glycoprotein-induced fusion

Scott Koenig, Vanessa M Hirsch, Robert A Olmsted, Douglas Powell, Wendy Maury, Arnold Rabson, Anthony S Fauci, Robert H Purcell and Philip R Johnson

Proceedings of the National Academy of Sciences - PNAS, Vol.86(7), pp.2443-2447

04/1989

DOI: 10.1073/pnas.86.7.2443

PMCID: PMC286929

PMID: 2784571

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Abstract

Simian immunodeficiency virus (SIV) and human immunodeficiency virus share the property of tropism for CD4-bearing cells. Infection is initiated by a high-affinity interaction between CD4 and conserved domains on the viral envelope glycoprotein. In this report, we demonstrated that SIV had a restricted host range among human CD4+ cells when compared with human immunodeficiency virus type 1 or type 2. This restricted tropism was associated with the inability of the SIV envelope glycoprotein to induce membrane fusion in cells not susceptible to productive exogenous infection by SIV. We conclude that the major route of SIV entry into CD4+ cells is by envelope-mediated direct fusion with the cell and that additional envelope-cell interactions after CD4 binding are required for productive infection.

Details

Title: Subtitle: Selective infection of human CD4+ cells by simian immunodeficiency virus: productive infection associated with envelope glycoprotein-induced fusion
Creators: Scott Koenig - Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892
Vanessa M Hirsch - Georgetown University
Robert A Olmsted - Georgetown University
Douglas Powell - Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892
Wendy Maury - Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892
Arnold Rabson - Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892
Anthony S Fauci - Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892
Robert H Purcell - Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892
Philip R Johnson - Georgetown University
Resource Type: Journal article
Publication Details: Proceedings of the National Academy of Sciences - PNAS, Vol.86(7), pp.2443-2447
DOI: 10.1073/pnas.86.7.2443
PMID: 2784571
PMCID: PMC286929
NLM abbreviation: Proc Natl Acad Sci U S A
ISSN: 0027-8424
eISSN: 1091-6490
Publisher: National Academy of Sciences
Language: English
Date published: 04/1989
Academic Unit: Microbiology and Immunology
Record Identifier: 9984083834802771

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