Journal article
Selective leptin resistance: a new concept in leptin physiology with cardiovascular implications
Journal of hypertension, Vol.20(7), pp.1245-1250
07/2002
DOI: 10.1097/00004872-200207000-00001
PMID: 12131511
Abstract
Leptin, an adipocyte secreted hormone, acts in the hypothalamus to inhibit appetite and promote thermogenic metabolism, thereby reducing adiposity and body weight. Leptin has multiple autonomic and cardiovascular actions, including sympathetic activation, increases in endothelium derived nitric oxide (NO), and angiogenesis. The predominant cardiovascular effect of chronic hyperleptinemia is a pressor effect mediated by increased sympathetic activity. The sympathetic and cardiovascular actions of leptin are discussed and evidence derived from studies of obese mice for the novel concept of selective leptin resistance is reviewed. This concept holds that in some obese states, there is preservation of the sympathoexcitatory actions of leptin despite resistance to the satiety and weight-reducing actions of the hormone. Selective leptin resistance might explain how hyperleptinemia could contribute to increases in sympathetic activity and arterial pressure in obese states where there is resistance to the metabolic (satiety and weight-reducing) actions of leptin. It is speculated here, that this concept may have potential implications for human obesity, which is often associated with elevated plasma leptin and partial resistance to the satiety effects of leptin. If selective leptin resistance occurs in obese humans, then leptin could contribute to the sympathetic overactivity and hypertension despite resistance to its metabolic actions.
Details
- Title: Subtitle
- Selective leptin resistance: a new concept in leptin physiology with cardiovascular implications
- Creators
- Allyn L Mark - Hypertension Genetics Specialized Center of Research, the Department of Internal Medicine, University of Iowa College of Medicine and the Veterans Administration Medical Center, Iowa City, Iowa, USA. allyn-mark@uiowa.eduMarcelo L G CorreiaKamal RahmouniWilliam G Haynes
- Resource Type
- Journal article
- Publication Details
- Journal of hypertension, Vol.20(7), pp.1245-1250
- Publisher
- England
- DOI
- 10.1097/00004872-200207000-00001
- PMID
- 12131511
- ISSN
- 0263-6352
- eISSN
- 1473-5598
- Grant note
- HL44546 / NHLBI NIH HHS
- Language
- English
- Date published
- 07/2002
- Academic Unit
- Iowa Neuroscience Institute; Neuroscience and Pharmacology; Endocrinology and Metabolism; Internal Medicine
- Record Identifier
- 9984040589502771
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