Selective loss of inner retinal layer thickness in type 1 diabetic patients with minimal diabetic retinopathy

Hille W van Dijk; Pauline H B Kok; Mona Garvin; Milan Sonka; J Hans Devries; Robert P J Michels; Mirjam E J van Velthoven; Reinier O Schlingemann; Frank D Verbraak; Michael D Abràmoff

doi:10.1167/iovs.08-3143

Back

Selective loss of inner retinal layer thickness in type 1 diabetic patients with minimal diabetic retinopathy

Journal article

Peer reviewed

Selective loss of inner retinal layer thickness in type 1 diabetic patients with minimal diabetic retinopathy

Hille W van Dijk, Pauline H B Kok, Mona Garvin, Milan Sonka, J Hans Devries, Robert P J Michels, Mirjam E J van Velthoven, Reinier O Schlingemann, Frank D Verbraak and Michael D Abràmoff

Investigative ophthalmology & visual science, Vol.50(7), pp.3404-3409

07/2009

DOI: 10.1167/iovs.08-3143

PMCID: PMC2937215

PMID: 19151397

Files and links (1)

url

http://dspace.library.uu.nl:8080/handle/1874/204345View

Open Access

Abstract

To determine whether type 1 diabetes preferentially affects the inner retinal layers by comparing the thickness of six retinal layers in type 1 diabetic patients who have no or minimal diabetic retinopathy (DR) with those of age- and sex-matched healthy controls. Fifty-seven patients with type 1 diabetes with no (n = 32) or minimal (n = 25) DR underwent full ophthalmic examination, stereoscopic fundus photography, and optical coherence tomography (OCT). After automated segmentation of intraretinal layers of the OCT images, mean thickness was calculated for six layers of the retina in the fovea, the pericentral area, and the peripheral area of the central macula and were compared with those of an age- and sex-matched control group. In patients with minimal DR, the mean ganglion cell/inner plexiform layer was 2.7 microm thinner (95% confidence interval [CI], 2.1-4.3 microm) and the mean inner nuclear layer was 1.1 microm thinner (95% CI, 0.1-2.1 microm) in the pericentral area of the central macula compared to those of age-matched controls. In the peripheral area, the mean ganglion cell/inner plexiform layer remained significantly thinner. No other layers showed a significant difference. Thinning of the total retina in type 1 diabetic patients with minimal retinopathy compared with healthy controls is attributed to a selective thinning of inner retinal layers and supports the concept that early DR includes a neurodegenerative component.

Photography

Algorithms

Glycated Hemoglobin A - analysis

Retinal Degeneration - diagnosis

Tomography, Optical Coherence

Humans

Male

Retinal Degeneration - etiology

Diabetes Mellitus, Type 1 - complications

Adult

Female

Retinal Neurons - pathology

Diabetic Retinopathy - etiology

Details

Title: Subtitle: Selective loss of inner retinal layer thickness in type 1 diabetic patients with minimal diabetic retinopathy
Creators: Hille W van Dijk - Department of Ophthalmology, Academic Medical Center, Amsterdam, the Netherlands. h.w.vandijk@amc.nl
Pauline H B Kok
Mona Garvin
Milan Sonka
J Hans Devries
Robert P J Michels
Mirjam E J van Velthoven
Reinier O Schlingemann
Frank D Verbraak
Michael D Abràmoff
Resource Type: Journal article
Publication Details: Investigative ophthalmology & visual science, Vol.50(7), pp.3404-3409
DOI: 10.1167/iovs.08-3143
PMID: 19151397
PMCID: PMC2937215
NLM abbreviation: Invest Ophthalmol Vis Sci
ISSN: 0146-0404
eISSN: 1552-5783
Publisher: United States
Grant note: R01 EB004640-01A2 / NIBIB NIH HHS R01 EB004640 / NIBIB NIH HHS R01 EY017066 / NEI NIH HHS R01 EY019112 / NEI NIH HHS R01 EY019112-01A2 / NEI NIH HHS R01 EY018853-01A2 / NEI NIH HHS R01 EY018853 / NEI NIH HHS R01-EY017066 / NEI NIH HHS
Language: English
Date published: 07/2009
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Electrical and Computer Engineering; Radiation Oncology; Injury Prevention Research Center; Ophthalmology and Visual Sciences
Record Identifier: 9983806389602771

Metrics

31 Record Views

305 Times Cited - Web of Science