Journal article
Selective role of the translin/trax RNase complex in hippocampal synaptic plasticity
Molecular brain, Vol.13(1), pp.145-145
11/10/2020
DOI: 10.1186/s13041-020-00691-5
PMCID: PMC7653721
PMID: 33172471
Abstract
Activity-dependent local protein synthesis is critical for synapse-specific, persistent plasticity. Abnormalities in local protein synthesis have been implicated in psychiatric disorders. We have recently identified the translin/trax microRNA-degrading enzyme as a novel mediator of protein synthesis at activated synapses. Additionally, translin knockout (KO) mice, which lack translin/trax, exhibit some of the behavioral abnormalities found in a mouse model of fragile X syndrome (fragile X mental retardation protein-FMRP-KO mice). Therefore, identifying signaling pathways interacting with translin/trax to support persistent synaptic plasticity is a translationally relevant goal. Here, as a first step to achieve this goal, we have assessed the requirement of translin/trax for multiple hippocampal synaptic plasticity paradigms that rely on distinct molecular mechanisms. We found that mice lacking translin/trax exhibited selective impairment in a form of persistent hippocampal plasticity, which requires postsynaptic protein kinase A (PKA) activity. In contrast, enduring forms of plasticity that are dependent on presynaptic PKA were unaffected. Furthermore, these mice did not display exaggerated metabotropic glutamate receptor-mediated long-term synaptic depression (mGluR-LTD), a hallmark of the FMRP KO mice. On the contrary, translin KO mice exhibited deficits in N-methyl-D-aspartate receptor (NMDAR) dependent LTD, a phenotype not observed in the FMRP knockouts. Taken together, these findings demonstrate that translin/trax mediates long-term synaptic plasticity that is dependent on postsynaptic PKA signaling and suggest that translin/trax and FMRP play distinct roles in hippocampal synaptic plasticity.
Details
- Title: Subtitle
- Selective role of the translin/trax RNase complex in hippocampal synaptic plasticity
- Creators
- Alan Jung Park - Gogos Lab, Mortimer B. Zuckerman Mind Brain Behavior Institute, Jerome L. Greene Science Center, Columbia University, L5-053, 3227 Broadway, New York, NY, 10027, USA. alanjpark2014@gmail.comMahesh Shivarama Shetty - Iowa Neuroscience Institute, Carver College of Medicine, University of Iowa, 2312 Pappajohn Biomedical Discovery Building, 169 Newton Road, Iowa City, 52242, IA, USAJay M Baraban - The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USATed Abel - Iowa Neuroscience Institute, Carver College of Medicine, University of Iowa, 2312 Pappajohn Biomedical Discovery Building, 169 Newton Road, Iowa City, 52242, IA, USA. ted-abel@uiowa.edu
- Resource Type
- Journal article
- Publication Details
- Molecular brain, Vol.13(1), pp.145-145
- DOI
- 10.1186/s13041-020-00691-5
- PMID
- 33172471
- PMCID
- PMC7653721
- NLM abbreviation
- Mol Brain
- ISSN
- 1756-6606
- eISSN
- 1756-6606
- Publisher
- England
- Grant note
- R01 MH087463 / NIMH NIH HHS
- Language
- English
- Date published
- 11/10/2020
- Academic Unit
- Molecular Physiology and Biophysics; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neuroscience and Pharmacology; Biochemistry and Molecular Biology
- Record Identifier
- 9984070774102771
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