Journal article
Selectively modified microfluidic chip for solvent extraction of Radix Salvia Miltiorrhiza using three-phase laminar flow to provide double liquid-liquid interface area
Microfluidics and nanofluidics, Vol.9(2-3), pp.365-373
08/01/2010
DOI: 10.1007/s10404-009-0554-y
Abstract
Radix Salvia Miltiorrhiza, a famous herb medicine is widely used in China and limitedly used in USA, Japan, and other countries for the treatment of cardiovascular and cerebrovascular diseases. This herb medicine has two groups (non-polar and polar) of active ingredients with distinct clinical effects, and thus theses ingredients should be separately used to enhance therapeutic efficacy and reduce side effect. In this article, as an alternative of conventional mechanical shaking and separatory funnel, laminar flow extraction in microfluidic chip is proposed to separate the two kinds of herb ingredients. Compared with conventional methods, microfluidic chip provides continuous extraction, less labor intensity, and better performance. Furthermore, we employ three-phase laminar flow to provide double liquid-liquid interface area, circumventing the low efficiency of two-phase laminar flow. Therefore, the extraction ratio is dramatically improved to 92% (tanshinone IIA). To predict the extraction ratio, a straightforward theoretical model is also established and agrees well with the experimental results. This microfluidic chip would be a powerful technical platform for handling complicated natural products.
Details
- Title: Subtitle
- Selectively modified microfluidic chip for solvent extraction of Radix Salvia Miltiorrhiza using three-phase laminar flow to provide double liquid-liquid interface area
- Creators
- Xuan Mu - East China University of Science and TechnologyQionglin Liang - Tsinghua UniversityPing Hu - East China University of Science and TechnologyKangning Ren - Tsinghua UniversityYiming Wang - Tsinghua UniversityGuoan Luo - East China University of Science and Technology
- Resource Type
- Journal article
- Publication Details
- Microfluidics and nanofluidics, Vol.9(2-3), pp.365-373
- Publisher
- Springer Nature
- DOI
- 10.1007/s10404-009-0554-y
- ISSN
- 1613-4982
- eISSN
- 1613-4990
- Number of pages
- 9
- Grant note
- 20080031012 / Ministry of Education of China; Ministry of Education, China 2007CB714505 / National Basic Research Program of China
- Language
- English
- Date published
- 08/01/2010
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering
- Record Identifier
- 9984277458902771
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