Journal article
Selectivity of action of 5-FU: biochemical basis
Bulletin du cancer, Vol.66(1), pp.43-47
01/01/1979
PMID: 154352
Abstract
Studies have been initiated to investigate the biochemical basis for selectivity of action of 5-fluorouracil against tumor cells. These studies included the measurement of 5-fluorodeoxyuridine monophosphate pools and the amount of 5-fluorouracil incorporated into RNA at various times following the administration of labeled 5-fluorouracil-6-3H, 5-fluorouridine-6-3H and 5-fluorodeoxyuridine-6-3H to animals bearing sensitive L1210 cells and L1210 resistant to 5-fluorouracil. The data indicate that: 1) in both cell lines the order of drug uptake into cells in vivo was in the order of fluorouride greater than fluorouracil greater then fluorodeoxyuridine; 2) there was no qualitative difference between the two cell lines in term of the extent of drug activation; 3) the data suggest a strong correlation between the amount of 5-fluorodeoxyuridine-monophosphates formed and retained at the target site and responsiveness to these agents. The effects of thymidine administered by continuous infusion and i.v. bolus injection on the antitumor activity of 5-fluorouracil was also investigated in animals bearing the induced colon carcinoma. The data suggest that thymidine, in combination with 5-fluorouracil, improves the therapeutic index of 5-fluorouracil. Initial studies on the metabolism of 5-fluorouracil in patients bearing the colon carcinoma are also reported herein.
Details
- Title: Subtitle
- Selectivity of action of 5-FU: biochemical basis
- Creators
- Y M RustumL DanhauserG Wang
- Resource Type
- Journal article
- Publication Details
- Bulletin du cancer, Vol.66(1), pp.43-47
- PMID
- 154352
- ISSN
- 0007-4551
- eISSN
- 1769-6917
- Language
- English
- Date published
- 01/01/1979
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
- Record Identifier
- 9984360152202771
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