Journal article
Selenium supplementation enhances low selenium levels and stimulates glutathione peroxidase activity in peripheral blood and distal colon mucosa in past and present carriers of colon adenomas
Nutrition and cancer, Vol.46(2), pp.125-130
01/01/2003
DOI: 10.1207/S15327914NC4602_04
PMID: 14690787
Abstract
Abstract: Selenoproteins such as glutathione peroxidases (GPx), thioredoxin reductases (TrxR), and selenoprotein P (SePP) contain molecular selenium in form of selenocysteines within their active center. They are involved in the defense of reactive oxygen species, which otherwise may cause DNA damage and alterations of protein function. Selenium intake has been linked to colon carcinogenesis in epidemiological and interventional studies. In a double-blinded, placebo-controlled trial, we demonstrate that carriers of colon adenomas present with low basal serum levels of selenium and plasma glutathione peroxidase (pGPx) activity before treatment, but both parameters can be normalized by interventional selenium supplementation. GPx activity in colon mucosa was enhanced in the verum group, albeit this had only borderline significance. No change of activity was observed for mucosal TrxR activity on selenium supplementation. In summary, our results confirm the existence of low selenium levels in patients prone to colon adenomas and show that by selenium supplementation this can be normalized. If prospective trials confirm that selenium supplementation reduces colon cancer incidence rates, it may be concluded that selenium supplementation should be recommended for patients at risk.
Details
- Title: Subtitle
- Selenium supplementation enhances low selenium levels and stimulates glutathione peroxidase activity in peripheral blood and distal colon mucosa in past and present carriers of colon adenomas
- Creators
- Oliver H AL-TAIE - Medizinische Poliklinik, Abteilung Molekulare Innere Medizin, Universität Würzburg, GermanyJochen Seufert - Medizinische Poliklinik, Abteilung Molekulare Innere Medizin, Universität Würzburg, GermanySerhan Karvar - Medizinische Poliklinik, Abteilung Molekulare Innere Medizin, Universität Würzburg, GermanyChristian Adolph - Medizinische Poliklinik, Abteilung Molekulare Innere Medizin, Universität Würzburg, GermanyHubert Mörk - Medizinische Poliklinik, Abteilung Molekulare Innere Medizin, Universität Würzburg, GermanyMichael Scheurlen - Medizinische Poliklinik, Universität, Würzburg, GermanyJosef Köhrle - Medizinische Poliklinik, Abteilung Molekulare Innere Medizin, Universität Würzburg, GermanyFranz Jakob - Medizinische Poliklinik, Abteilung Molekulare Innere Medizin, Universität Würzburg, Germany
- Resource Type
- Journal article
- Publication Details
- Nutrition and cancer, Vol.46(2), pp.125-130
- Publisher
- Taylor& Francis
- DOI
- 10.1207/S15327914NC4602_04
- PMID
- 14690787
- ISSN
- 0163-5581
- eISSN
- 1532-7914
- Language
- English
- Date published
- 01/01/2003
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984695683902771
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