Selenoprotein P in colitis-associated carcinoma

Sarah P. Short; Caitlyn Whitten-Barrett; Christopher S. Williams

doi:10.1080/23723556.2015.1075094

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Selenoprotein P in colitis-associated carcinoma

Journal article

Open access

Selenoprotein P in colitis-associated carcinoma

Sarah P. Short, Caitlyn Whitten-Barrett and Christopher S. Williams

Molecular & cellular oncology, Vol.3(3), pp.e1075094-e1075094

05/03/2016

DOI: 10.1080/23723556.2015.1075094

PMCID: PMC4909462

PMID: 27314080

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https://doi.org/10.1080/23723556.2015.1075094View

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Abstract

Patients with inflammatory bowel disease are often deficient in micronutrients such as selenium and have an increased risk of colon cancer. We tested whether the selenium transport protein, selenoprotein P, could modify colitis-associated cancer. Our results indicate that global SEPP1 haploinsufficiency augments tumorigenesis and mediates oxidative damage in the intestine.

Cancer

IBD

selenoprotein P

SEPP1

ulcerative colitis

Details

Title: Subtitle: Selenoprotein P in colitis-associated carcinoma
Creators: Sarah P. Short - Vanderbilt University
Caitlyn Whitten-Barrett - Vanderbilt University
Christopher S. Williams - Vanderbilt University
Resource Type: Journal article
Publication Details: Molecular & cellular oncology, Vol.3(3), pp.e1075094-e1075094
Publisher: Taylor & Francis
DOI: 10.1080/23723556.2015.1075094
PMID: 27314080
PMCID: PMC4909462
ISSN: 2372-3556
eISSN: 2372-3556
Language: English
Date published: 05/03/2016
Academic Unit: Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
Record Identifier: 9984420844702771

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