Journal article
Selenoproteins and oxidative stress-induced inflammatory tumorigenesis in the gut
Cellular and molecular life sciences : CMLS, Vol.74(4), pp.607-616
02/01/2017
DOI: 10.1007/s00018-016-2339-2
PMCID: PMC5274549
PMID: 27563706
Abstract
Selenium is an essential micronutrient that is incorporated into at least 25 selenoproteins encoded by the human genome, many of which serve antioxidant functions. Because patients with inflammatory bowel disease (IBD) demonstrate nutritional deficiencies and are at increased risk for colon cancer due to heightened inflammation and oxidative stress, selenoprotein dysfunction may contribute to disease progression. Over the years, numerous studies have analyzed the effects of selenoprotein loss and shown that they are important mediators of intestinal inflammation and carcinogenesis. In particular, recent work has focused on the role of selenoprotein P (SEPP1), a major selenium transport protein which also has endogenous antioxidant function. These experiments determined SEPP1 loss altered immune and epithelial cellular function in a murine model of colitis-associated carcinoma. Here, we discuss the current knowledge of SEPP1 and selenoprotein function in the setting of IBD, colitis, and inflammatory tumorigenesis.
Details
- Title: Subtitle
- Selenoproteins and oxidative stress-induced inflammatory tumorigenesis in the gut
- Creators
- Caitlyn W. Barrett - University of PittsburghSarah P. Short - Vanderbilt UniversityChristopher S. Williams - Vanderbilt University
- Resource Type
- Journal article
- Publication Details
- Cellular and molecular life sciences : CMLS, Vol.74(4), pp.607-616
- DOI
- 10.1007/s00018-016-2339-2
- PMID
- 27563706
- PMCID
- PMC5274549
- NLM abbreviation
- Cell Mol Life Sci
- ISSN
- 1420-682X
- eISSN
- 1420-9071
- Publisher
- Springer Nature
- Number of pages
- 10
- Grant note
- F31CA167920 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) T32 GM007347 / NIGMS NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS) 1I01BX001426-01A1 / VA; US Department of Veterans Affairs I01BX001426 / Veterans Affairs; US Department of Veterans Affairs T32GM007347 / NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS) L30 RR032065 / NCRR NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) F31 CA167920 / NCI NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) I01 BX001426 / BLRD VA L30 DK076274; K08 DK080221; F32 DK108492; R01 DK099204 / NIDDK NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) K08DK080221 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK)
- Language
- English
- Date published
- 02/01/2017
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
- Record Identifier
- 9984420843802771
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