Journal article
Self-Collected Vaginal Specimens for HPV Testing: Recommendations From the Enduring Consensus Cervical Cancer Screening and Management Guidelines Committee
Journal of lower genital tract disease, Vol.29(2), pp.144-152
04/2025
DOI: 10.1097/LGT.0000000000000885
PMCID: PMC11939108
PMID: 39982254
Abstract
The Enduring Consensus Cervical Cancer Screening and Management Guidelines Committee developed recommendations for the use of self-collected vaginal specimens for human papillomavirus (HPV) testing in health care settings.
A comprehensive literature search was performed, external systematic reviews were evaluated, and HPV genotype agreement between self-collected vaginal and clinician-collected cervical specimens was summarized. Recommendations considered available data, public comments, and expert consensus. Recommendations were ratified through a vote by the Consensus Stakeholder Group.
Clinician-collected cervical specimens are preferred and self-collected vaginal specimens are acceptable for primary HPV screening of asymptomatic average-risk individuals. Repeat testing in 3 years is recommended following HPV-negative screens using self-collected vaginal specimens. Colposcopy with collection of cytology and biopsies is recommended following positive tests for HPV types 16 and 18. Clinician-collected cytology or dual stain for triage testing is recommended following positive tests for HPV 45, 33/58, 31, 52, 35/39/68, or 51 or for pooled HPV other types but negative for HPV 16 or 18. Repeat HPV testing in 1 year is recommended following a positive test for HPV types 56/59/66 and no other carcinogenic types. Minimal data exist on use of self-collected vaginal specimens for surveillance following abnormal screening test results, colposcopy or treatment, and therefore, clinician-collected cervical specimens are preferred.
Human papillomavirus testing of self-collected vaginal specimens expands cervical cancer screening options and has potential to increase access for currently underscreened individuals. Laboratory and clinical workflows will need to be modified to ensure adequate specimen processing and follow-up.
Details
- Title: Subtitle
- Self-Collected Vaginal Specimens for HPV Testing: Recommendations From the Enduring Consensus Cervical Cancer Screening and Management Guidelines Committee
- Creators
- Nicolas Wentzensen - National Cancer InstituteL Stewart Massad - Washington University in St. LouisMegan A Clarke - National Cancer InstituteFrancisco Garcia - University of ArizonaRobert Smith - American Cancer SocietyJeanne Murphy - Johns Hopkins MedicineRichard Guido - University of PittsburghAna Reyes - Cervivor, Inc., Upper Marlboro, MDSarah Phillips - Division of Cancer Epidemiology and GeneticsNancy Berman - Michigan Healthcare ProfessionalsJeffrey Quinlan - University of IowaEileen Lind - Team Maureen, Falmouth, MARebecca B Perkins - Tufts Medical CenterEnduring Consensus Cervical Cancer Screening and Management Guidelines Committee
- Resource Type
- Journal article
- Publication Details
- Journal of lower genital tract disease, Vol.29(2), pp.144-152
- DOI
- 10.1097/LGT.0000000000000885
- PMID
- 39982254
- PMCID
- PMC11939108
- NLM abbreviation
- J Low Genit Tract Dis
- ISSN
- 1526-0976
- eISSN
- 1526-0976
- Publisher
- LIPPINCOTT WILLIAMS & WILKINS
- Language
- English
- Electronic publication date
- 02/21/2025
- Date published
- 04/2025
- Academic Unit
- Family and Community Medicine
- Record Identifier
- 9984790993602771
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