Journal article
Self-Generated Whisker Movements Drive State-Dependent Sensory Input to Developing Barrel Cortex
Current biology, Vol.30(12), pp.2404-2410.e4
05/06/2020
DOI: 10.1016/j.cub.2020.04.045
PMID: 32413304
Abstract
Cortical development is an activity-dependent process [1-3]. Regarding the role of activity in the developing somatosensory cortex, one persistent debate concerns the importance of sensory feedback from self-generated movements. Specifically, recent studies claim that cortical activity is generated intrinsically, independent of movement [3, 4]. However, other studies claim that behavioral state moderates the relationship between movement and cortical activity [5-7]. Thus, perhaps inattention to behavioral state leads to failures to detect movement-driven activity [8]. Here, we resolve this issue by associating local field activity (i.e., spindle bursts) and unit activity in the barrel cortex of 5-day-old rats with whisker movements during wake and myoclonic twitches of the whiskers during active (REM) sleep. Barrel activity increased significantly within 500 ms of whisker movements, especially after twitches. Also, higher-amplitude movements were more likely to trigger barrel activity; when we controlled for movement amplitude, barrel activity was again greater after a twitch than a wake movement. We then inverted the analysis to assess the likelihood that increases in barrel activity were preceded within 500 ms by whisker movements: at least 55% of barrel activity was attributable to sensory feedback from whisker movements. Finally, when periods with and without movement were compared, 70%-75% of barrel activity was movement related. These results confirm the importance of sensory feedback from movements in driving activity in sensorimotor cortex and underscore the necessity of monitoring sleep-wake states to ensure accurate assessments of the contributions of the sensory periphery to activity in developing somatosensory cortex.
Details
- Title: Subtitle
- Self-Generated Whisker Movements Drive State-Dependent Sensory Input to Developing Barrel Cortex
- Creators
- James C Dooley - Department of Psychological & Brain Sciences, University of Iowa, Iowa City, IA 52242, USA; DeLTA Center, University of Iowa, Iowa City, IA 52242 USA. Electronic address: james-c-dooley@uiowa.eduRyan M Glanz - Department of Psychological & Brain Sciences, University of Iowa, Iowa City, IA 52242, USAGreta Sokoloff - Department of Psychological & Brain Sciences, University of Iowa, Iowa City, IA 52242, USA; DeLTA Center, University of Iowa, Iowa City, IA 52242 USA; Iowa Neuroscience Institute, University of Iowa, Iowa City, IA 52242 USAMark S Blumberg - Department of Psychological & Brain Sciences, University of Iowa, Iowa City, IA 52242, USA; Interdisciplinary Graduate Program in Neuroscience, University of Iowa, Iowa City, IA 52242, USA; DeLTA Center, University of Iowa, Iowa City, IA 52242 USA; Iowa Neuroscience Institute, University of Iowa, Iowa City, IA 52242 USA. Electronic address: mark-blumberg@uiowa.edu
- Resource Type
- Journal article
- Publication Details
- Current biology, Vol.30(12), pp.2404-2410.e4
- Publisher
- England
- DOI
- 10.1016/j.cub.2020.04.045
- PMID
- 32413304
- ISSN
- 0960-9822
- eISSN
- 1879-0445
- Grant note
- DOI: 10.13039/100000002, name: National Institutes of Health
- Language
- English
- Date published
- 05/06/2020
- Academic Unit
- Psychological and Brain Sciences; Iowa Neuroscience Institute; Biology
- Record Identifier
- 9984070227302771
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