Journal article
Self-Paced Timing Detects and Tracks Change in Prodromal Huntington Disease
Neuropsychology, Vol.24(4), pp.435-442
07/2010
DOI: 10.1037/a0018905
PMCID: PMC2900808
PMID: 20604618
Abstract
Objective:
This study compares self-paced timing performance (cross-sectionally and longitudinally) between participants with prodromal Huntington's disease (
pr
-HD) and a comparison group of gene non-expanded participants from affected families (NC).
Method:
Participants (747
pr
-HD: 188 NC) listened to tones presented at 550-ms intervals, matched that pace by tapping response keys and continued the rhythm (self-paced) after the tone had stopped. Standardized cross-sectional and longitudinal linear models examined the relationships between self-paced timing precision and estimated proximity to diagnosis, and other demographic factors.
Results:
Pr
-HD participants showed significantly less timing precision than NC. Comparison of
pr
-HD and NC participants showed a significant performance difference on two task administration conditions (dominant hand:
p
< .0001; alternating thumbs:
p
< .0001). Additionally, estimated proximity to diagnosis was related to timing precision in both conditions, (dominant hand:
t
= −11.14,
df
= 920,
p
< .0001; alternating thumbs:
t
= −11.32,
df
= 918,
p
< .0001). Longitudinal modeling showed that
pr
-HD participants worsen more quickly at the task than the NC group, and rate of decline increases with estimated proximity to diagnosis in both conditions (dominant hand:
t
= −2.85,
df
= 417,
p
= .0045; alternating thumbs:
t
= −3.56,
df
= 445,
p
= .0004). Effect sizes based on adjusted mean annual change ranged from −0.34 to 0.25 in the longitudinal model.
Conclusions:
The self-paced timing paradigm has potential for use as a screening tool and outcome measure in
pr
-HD clinical trials to gauge therapeutically mediated improvement or maintenance of function.
Details
- Title: Subtitle
- Self-Paced Timing Detects and Tracks Change in Prodromal Huntington Disease
- Creators
- Kelly C Rowe - Department of Psychiatry and Interdepartmental Neuroscience Program, University of Iowa Carver College of MedicineJane S Paulsen - Department of Psychiatry, Interdepartmental Neuroscience Program, Department of Neurology, and Department of Psychology, University of Iowa Carver College of MedicineDouglas R Langbehn - Department of Psychiatry, Department of Biostatistics, University of Iowa Carver College of MedicineKevin Duff - Department of Psychiatry, University of Iowa Carver College of MedicineLeigh J Beglinger - Department of Psychiatry, University of Iowa Carver College of MedicineChiachi Wang - Department of Psychiatry, University of Iowa Carver College of MedicineJustin J. F O'Rourke - Department of Psychiatry, Counseling Psychology, University of Iowa Carver College of MedicineJulie C Stout - Department of Psychology, Indiana University in Bloomington and School of Psychology, Psychiatry, and Psychological Medicine, Monash UniversityDavid J Moser - Department of Psychiatry, and Interdepartmental Neuroscience Program, University of Iowa Carver College of MedicinePREDICT-HD Investigators of the Huntington Study Group
- Resource Type
- Journal article
- Publication Details
- Neuropsychology, Vol.24(4), pp.435-442
- DOI
- 10.1037/a0018905
- PMID
- 20604618
- PMCID
- PMC2900808
- NLM abbreviation
- Neuropsychology
- ISSN
- 0894-4105
- eISSN
- 1931-1559
- Publisher
- American Psychological Association
- Grant note
- DOI: 10.13039/100000002, name: National Institutes of Health, award: 2RO1 NS0040068; DOI: 10.13039/100005725, name: CHDI
- Language
- English
- Date published
- 07/2010
- Academic Unit
- Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Medicine Administration
- Record Identifier
- 9984003906602771
Metrics
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