Journal article
Self-focused brain predictors of cognitive behavioral therapy response in a transdiagnostic sample
Journal of psychiatric research, Vol.17, pp.108-115
03/2024
DOI: 10.1016/j.jpsychires.2024.01.018
PMCID: PMC10922639
PMID: 38266332
Abstract
Background
Effective biomarkers of cognitive behavioral therapy (CBT) response provide information beyond available behavioral or self-report measures and may optimize treatment selection for patients based on likelihood of benefit. No single biomarker reliably predicts CBT response. In this study, we evaluated patterns of brain connectivity associated with self-focused attention (SFA) as biomarkers of CBT response for anxiety and obsessive-compulsive disorders. We hypothesized that pre-treatment as well as pre-to post-treatment changes in functional connectivity would be associated with improvement during CBT in a transdiagnostic sample.
Methods
Twenty-seven patients with primary social anxiety disorder (n = 14) and primary body dysmorphic disorder (n = 13) were scanned before and after 12 sessions of CBT targeting their primary disorder. Eligibility was based on elevated trait SFA scores on the Public Self-Consciousness Scale. Seed-based resting state functional connectivity associated with symptom improvement was computed using a seed in the posterior cingulate cortex of the default mode network.
Results
At pre-treatment, stronger positive connectivity of the seed with the cerebellum, and stronger negative connectivity with the putamen, were associated with greater clinical improvement. Between pre-to post-treatment, greater anticorrelation between the seed and postcentral gyrus, extending into the inferior parietal lobule and precuneus/superior parietal lobule was associated with clinical improvement, although this did not survive thresholding.
Conclusions
Pre-treatment functional connectivity with the default mode network was associated with CBT response. Behavioral and self-report measures of SFA did not contribute to predictions, thus highlighting the value of neuroimaging-based measures of SFA.
Details
- Title: Subtitle
- Self-focused brain predictors of cognitive behavioral therapy response in a transdiagnostic sample
- Creators
- Angela Fang - University of WashingtonBengi Baran - University of IowaJamie D. Feusner - Centre for Addiction and Mental HealthK. Luan Phan - The Ohio State University Wexner Medical CenterClare C. Beatty - Stony Brook UniversityJessica CraneRyan J. Jacoby - Massachusetts General HospitalDara S. Manoach - Harvard UniversitySabine Wilhelm - Massachusetts General Hospital
- Resource Type
- Journal article
- Publication Details
- Journal of psychiatric research, Vol.17, pp.108-115
- Publisher
- Elsevier BV
- DOI
- 10.1016/j.jpsychires.2024.01.018
- PMID
- 38266332
- PMCID
- PMC10922639
- ISSN
- 0022-3956
- eISSN
- 1879-1379
- Grant note
- DOI: 10.13039/100000025, name: National Institute of Mental Health, award: K01 MH114012, K23 MH109593, K23 MH120351, R01MH121520, R21MH128815
- Language
- English
- Electronic publication date
- 01/16/2024
- Date published
- 03/2024
- Academic Unit
- Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984548409602771
Metrics
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