Journal article
Self-reported Snoring and Risk of Cardiovascular Disease among Postmenopausal Women (From the Women’s Health Initiative)
The American journal of cardiology, Vol.111(4), pp.540-546
12/04/2012
DOI: 10.1016/j.amjcard.2012.10.039
PMCID: PMC3563849
PMID: 23219175
Abstract
Habitual snoring may be associated with cardiovascular disease (CVD); however limited evidence exists among women. We investigated whether frequent snoring is a predictor of coronary heart disease (CHD) and stroke among 42,244 postmenopausal women participating in the Women’s Health Initiative Observational Study. Participants provided self-reported information regarding snoring habits at baseline (1993-1998) and were followed for outcomes through August 2009. Physician adjudicators confirmed CHD, defined as MI, CHD death, revascularization procedures, or hospitalized angina, and confirmed ischemic stroke. Cox proportional hazards models were used to evaluate whether snoring frequency is a significant predictor of adjudicated outcomes. We observed 2,401 incident cases of CHD over 437,899 person-years of follow up. After adjusting for age and race, frequent snoring was associated with incident CHD (HR=1.54, 95% CI 1.39-1.70) and stroke (HR=1.41, 95% CI 1.19-1.66), and all CVD (HR=1.46, 95% CI 1.34-1.60). In fully adjusted models that included CVD risk factors such as obesity, hypertension, and diabetes, frequent snoring was associated with a more modest increase in incident CHD (HR=1.14 95% CI 1.01-1.28), stroke (HR=1.19, 95% CI 1.02-1.40) and CVD (HR=1.12, 95% CI 1.01-1.24). In conclusion, snoring is associated with a modest increased risk of incident CHD, stroke and CVD after adjustment for CVD risk factors. Additional studies are needed to elucidate the mechanisms in which snoring may be associated with CVD risk factors and outcomes.
Details
- Title: Subtitle
- Self-reported Snoring and Risk of Cardiovascular Disease among Postmenopausal Women (From the Women’s Health Initiative)
- Creators
- Megan Sands - University of PennsylvaniaEric B. Loucks - Brown UniversityBing Lu - Brigham and Women's HospitalMary A. Carskadon - Brown UniversityKatherine Sharkey - Brown UniversityMarcia Stefanick - Stanford UniversityJudith Ockene - University of Massachusetts Chan Medical SchoolNeomi Shah - Albert Einstein College of MedicineKristen G. Hairston - Wake Forest UniversityJennifer Robinson - University of IowaMarian Limacher - University of FloridaLauren Hale - Stony Brook UniversityCharles B. Eaton - Brown University
- Resource Type
- Journal article
- Publication Details
- The American journal of cardiology, Vol.111(4), pp.540-546
- DOI
- 10.1016/j.amjcard.2012.10.039
- PMID
- 23219175
- PMCID
- PMC3563849
- ISSN
- 0002-9149
- eISSN
- 1879-1913
- Language
- English
- Date published
- 12/04/2012
- Academic Unit
- Epidemiology; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9984363625702771
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