Journal article
Self-reported Tobacco use does not correlate with carcinogen exposure in smokers with head and neck cancer
The Laryngoscope, Vol.125(8), pp.1844-1848
08/2015
DOI: 10.1002/lary.25290
PMCID: PMC4512915
PMID: 25877866
Abstract
Objectives/HypothesisHead and neck squamous cell carcinoma (HNSCC) is strongly associated with tobacco use. We sought to examine the relationship between self-reported tobacco use and the level of urinary tobacco carcinogen metabolites in a cohort of patients with HNSCC.
Study DesignCross-sectional analysis.
MethodsEighty-four cigarette smokers with head and neck cancer completed tobacco and alcohol use questionnaires, and the following urinary tobacco metabolites were quantified: 1-hydroxypyrene (1-HOP), N'-nitrosonornicotine and its glucuronides (total NNN), 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol and its glucuronides (total NNAL), and cotinine. A cross-sectional analysis was performed with assessment of correlation coefficients.
ResultsWhen analyzed based on self-reported cigarettes per day (CPD), no significant correlation with any of the studied tobacco carcinogen metabolites was found. However, urinary cotinine showed significant correlation with total NNN, total NNAL, and 1-HOP. Total NNN, total NNAL, and 1-HOP showed significant correlation with each other suggesting exposure occurs to each proportionally.
ConclusionsIn smokers with HNSCC, self-reported tobacco use does not predict actual carcinogen exposure. In contrast, urinary cotinine levels significantly correlate with carcinogen levels. Therefore, urinary cotinine is the preferred value for estimating carcinogen dose in these patients. 1-HOP levels were significantly associated with total NNN and total NNAL suggesting that smokers are exposed to these carcinogens proportionally. These data indicate that utilizing conventional methods of estimating tobacco exposure (CPD) may not accurately approximate exposure to tobacco carcinogens in smokers with HNSCC. These data have implications for future studies focused on screening and epidemiology of smokers with HNSCC.
Level of EvidenceNA Laryngoscope, 125:1844-1848, 2015
Details
- Title: Subtitle
- Self-reported Tobacco use does not correlate with carcinogen exposure in smokers with head and neck cancer
- Creators
- Samir S. Khariwala - University of MinnesotaSteven G. Carmella - University of MinnesotaIrina Stepanov - University of MinnesotaDipankar Bandyopadhyay - University of MinnesotaHeather H. Nelson - University of MinnesotaBevan Yueh - University of MinnesotaDorothy K. Hatsukami - University of MinnesotaStephen S. Hecht - University of Minnesota
- Resource Type
- Journal article
- Publication Details
- The Laryngoscope, Vol.125(8), pp.1844-1848
- DOI
- 10.1002/lary.25290
- PMID
- 25877866
- PMCID
- PMC4512915
- NLM abbreviation
- Laryngoscope
- ISSN
- 0023-852X
- eISSN
- 1531-4995
- Publisher
- Wiley
- Number of pages
- 5
- Grant note
- K23 DE023572 / National Institute of Dental and Craniofacial Research; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Dental & Craniofacial Research (NIDCR) National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA P30CA077598 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) K23DE023572 / NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Dental & Craniofacial Research (NIDCR)
- Language
- English
- Date published
- 08/2015
- Academic Unit
- Otolaryngology
- Record Identifier
- 9984966848702771
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