Self-reported maternal cigarette smoke exposure during the periconceptional period and the risk for omphalocoele

Marcia L Feldkamp; Sivithee Srisukhumbowornchai; Paul A Romitti; Richard S Olney; Sandra D Richardson; Lorenzo D Botto; National Birth Defects Prevention Study

doi:10.1111/ppe.12093

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Self-reported maternal cigarette smoke exposure during the periconceptional period and the risk for omphalocoele

Journal article

Peer reviewed

Self-reported maternal cigarette smoke exposure during the periconceptional period and the risk for omphalocoele

Marcia L Feldkamp, Sivithee Srisukhumbowornchai, Paul A Romitti, Richard S Olney, Sandra D Richardson, Lorenzo D Botto and National Birth Defects Prevention Study

Paediatric and perinatal epidemiology, Vol.28(1), pp.67-73

01/2014

DOI: 10.1111/ppe.12093

PMCID: PMC4427045

PMID: 24313669

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Abstract

We investigated whether maternal exposure to cigarette smoke was associated with omphalocoele and whether periconceptional folic acid modified the association. : We analysed data from the National Birth Defects Prevention Study on omphalocoele case (n = 301) and control (n = 8135) mothers for infants born from 1997 through 2007. Mothers who reported active smoking or exposure to second-hand smoke during the periconceptional period (1 month before conception to 3 months after) were considered exposed. Those who reported use of folic acid supplements during the same period were considered supplement users. Odds ratios and 95% confidence intervals were estimated using multivariable logistic regression adjusted for alcohol use, preconception body mass index, and race/ethnicity. One hundred fifteen (38.2%) case and 2592 (31.9%) control mothers reported exposure to cigarette smoke during the periconceptional period. Adjusted odds ratios [95% confidence intervals] were 1.19 [0.94, 1.53] for any smoke exposure, 0.87 [0.54, 1.40] for active smoking, 1.38 [1.00, 1.90] for second-hand smoke exposure, and 1.16 [0.80, 1.67] for both exposures combined. No dose-response relationship was observed. Folic acid-containing supplements did not reduce the risk for omphalocoele among women with active or second-hand smoke exposure. Self-reported active maternal smoking, with or without exposure to second-hand smoke, during the periconceptional period was not associated with omphalocoele. In contrast, there was a possible association with periconceptional exposure to second-hand smoke.

Pregnancy

Smoking - adverse effects

Folic Acid - therapeutic use

Humans

Risk Factors

Self Report

Hernia, Umbilical - etiology

Maternal Exposure

Mothers

Tobacco Smoke Pollution - adverse effects

Hernia, Umbilical - prevention & control

Adult

Female

Odds Ratio

Dietary Supplements

Infant, Newborn

Prenatal Exposure Delayed Effects - pathology

Preconception Care

Details

Title: Subtitle: Self-reported maternal cigarette smoke exposure during the periconceptional period and the risk for omphalocoele
Creators: Marcia L Feldkamp - Department of Pediatrics, University of Utah, Salt Lake City, UT
Sivithee Srisukhumbowornchai
Paul A Romitti
Richard S Olney
Sandra D Richardson
Lorenzo D Botto
National Birth Defects Prevention Study
Resource Type: Journal article
Publication Details: Paediatric and perinatal epidemiology, Vol.28(1), pp.67-73
DOI: 10.1111/ppe.12093
PMID: 24313669
PMCID: PMC4427045
NLM abbreviation: Paediatr Perinat Epidemiol
ISSN: 0269-5022
eISSN: 1365-3016
Publisher: Wiley; England
Grant note: PA 02081 / PHS HHS FOA DD09-001 / NCBDD CDC HHS CC999999 / Intramural CDC HHS PA 96043 / PHS HHS U01 DD001035 / NCBDD CDC HHS
Language: English
Date published: 01/2014
Academic Unit: Epidemiology; Biostatistics
Record Identifier: 9983995133702771

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