Semaglutide in Cystic Fibrosis-Related Diabetes

Helen Gnanapragasam; Naghma Mustafa; Mary Bierbrauer; Tara Andrea Providence; Paresh Dandona

doi:10.1210/clinem/dgaa167

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Semaglutide in Cystic Fibrosis-Related Diabetes

Journal article

Open access

Peer reviewed

Semaglutide in Cystic Fibrosis-Related Diabetes

Helen Gnanapragasam, Naghma Mustafa, Mary Bierbrauer, Tara Andrea Providence and Paresh Dandona

The journal of clinical endocrinology and metabolism, Vol.105(7), pp.2341-2344

07/01/2020

DOI: 10.1210/clinem/dgaa167

PMID: 32232400

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Abstract

Abstract Context and Objective In spite of the evidence that inadequately controlled glycemia is associated with worse clinical outcomes, cystic fibrosis-related diabetes (CFRD) is not well controlled in a majority of patients. The objective of this report is to demonstrate the effect of the addition of semaglutide, a glucagon-like peptide-1 receptor agonist (GLP-1RA), to basal insulin to control glycemia in one such patient. Design, Intervention, and the Main Outcome Measures The replacement of rapidly acting prandial insulin with semaglutide weekly with continuation of basal insulin. Glycated hemoglobin A1c (HbA1c) was measured and continuous glucose monitoring (CGM) was conducted. Results There was a significant improvement in glycemic control, reduction in HbA1c from 9.1% to 6.7% and stable euglycemic pattern on CGM (mean glucose, 142 mg/dL; SD, 51) within 3 months of starting treatment. There was no increase in plasma pancreatic enzyme concentrations. Conclusions Semaglutide at a low dose was able to replace prandial insulin and control glycemia in combination with basal insulin.

Details

Title: Subtitle: Semaglutide in Cystic Fibrosis-Related Diabetes
Creators: Helen Gnanapragasam - University at Buffalo, State University of New York
Naghma Mustafa - University at Buffalo, State University of New York
Mary Bierbrauer - University at Buffalo, State University of New York
Tara Andrea Providence - Division of Endocrinology, Diabetes and Metabolism, State University of New York at Buffalo, Amherst, New York
Paresh Dandona - University at Buffalo, State University of New York
Resource Type: Journal article
Publication Details: The journal of clinical endocrinology and metabolism, Vol.105(7), pp.2341-2344
DOI: 10.1210/clinem/dgaa167
PMID: 32232400
ISSN: 0021-972X
eISSN: 1945-7197
Language: English
Date published: 07/01/2020
Academic Unit: Internal Medicine
Record Identifier: 9984359921602771

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