Journal article
Sense and antisense TGFβ3 mRNA levels correlate with cardiac valve induction
Developmental dynamics, Vol.193(4), pp.340-345
04/1992
DOI: 10.1002/aja.1001930407
PMID: 1511174
Abstract
The formation of the valves in the heart is a spatially and temporally controlled process. A tissue interaction between the endothelium and its adjacent myocardium initiates the transformation of the endothelium into the mesenchymal precursors of the heart valve. One or more of the molecules implicated as critical for valve formation are members of the transforming growth factor beta family of molecules. Presented here is a spatial and temporal analysis of TGF beta 2 and TGF beta 3 in the chick heart during valve formation. We show that TGF beta 3 mRNA is concentrated in AV canal tissue where valve formation will occur, consistent with previous observations that TGF beta 3 production is critical during valve formation. Additionally, an RNA complementary to TGF beta 3 encoding mRNA is present in the heart. The temporally controlled appearance of RNA complementary to TGF beta 3 suggests that this molecule may play a role in the regulation of TGF beta 3 production in the heart.
Details
- Title: Subtitle
- Sense and antisense TGFβ3 mRNA levels correlate with cardiac valve induction
- Creators
- J D Potts - Department of Anatomy, University of Iowa, Iowa City 52242E B VincentR B RunyanD L Weeks
- Resource Type
- Journal article
- Publication Details
- Developmental dynamics, Vol.193(4), pp.340-345
- DOI
- 10.1002/aja.1001930407
- PMID
- 1511174
- NLM abbreviation
- Dev Dyn
- ISSN
- 1058-8388
- eISSN
- 1097-0177
- Publisher
- United States
- Language
- English
- Date published
- 04/1992
- Academic Unit
- Stead Family Department of Pediatrics; Biochemistry and Molecular Biology
- Record Identifier
- 9984024532902771
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