Journal article
Sensitivity and sensitisation in relation to pain severity in knee osteoarthritis: trait or state?
Annals of the rheumatic diseases, Vol.74(4), pp.682-688
04/2015
DOI: 10.1136/annrheumdis-2013-204191
PMCID: PMC4062615
PMID: 24351516
Abstract
Objectives It is not clear whether heightened pain sensitivity in knee osteoarthritis (OA) is related to sensitisation induced by nociceptive input from OA pathology (‘state’) versus other confounding factors. Conversely, some individuals may be predisposed to sensitisation irrespective of OA (‘trait’). Methods The Multicenter Osteoarthritis Study is a longitudinal cohort of persons with or at risk of knee OA. We obtained knee X-rays, pain questionnaires and comprehensive assessment of factors that can influence pain sensitivity. We examined the relation of sensitisation and sensitivity assessed by mechanical temporal summation (TS) and pressure pain thresholds (PPTs) to knee OA and knee pain severity. To test whether sensitisation and sensitivity is a ‘state’ induced by OA pathology, we examined the relation of PPT and TS to knee OA duration and severity. Results In 2126 subjects (mean age 68, mean body mass index (BMI) 31, 61% female), PPT and TS were not associated with radiographic OA (ORs 0.9–1.0 for PPT and TS; p>0.05). However, PPT and TS were associated with pain severity (ORs: 1.7–2.0 for PPT; 1.3–1.6 for TS; p<0.05). Knee OA duration and radiographic severity were not associated with PPT or TS. Conclusions PPT and TS were associated with OA-related pain, but not radiographic OA after accounting for pertinent confounders in this large cohort. Lack of association with disease duration suggests at least some sensitisation and pain sensitivity may be a trait rather than state. Understanding the relationship between pathological pain and pain sensitivity/sensitisation offers insight into OA pain risk factors and pain management opportunities.
Details
- Title: Subtitle
- Sensitivity and sensitisation in relation to pain severity in knee osteoarthritis: trait or state?
- Creators
- Tuhina Neogi - Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, Massachusetts, USALaura Frey-Law - Department of Physical Therapy & Rehabilitation Science, University of Iowa, Iowa City, Iowa, USAJoachim Scholz - Department of Anesthesiology and Pharmacology, Columbia University Medical Center, New York, New York, USAJingbo Niu - Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, Massachusetts, USALars Arendt-Nielsen - Department of Health Science and Technology, Center for Sensory-Motor Interaction, Aalborg University, Aalborg, DenmarkClifford Woolf - F.M. Kirby Center and Program in Neurobiology, Children's Hospital Boston, Boston, Massachusetts, USAMichael Nevitt - Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, California, USALaurence Bradley - Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, Alabama, USADavid T Felson - Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, Massachusetts, USA
- Resource Type
- Journal article
- Publication Details
- Annals of the rheumatic diseases, Vol.74(4), pp.682-688
- DOI
- 10.1136/annrheumdis-2013-204191
- PMID
- 24351516
- PMCID
- PMC4062615
- NLM abbreviation
- Ann Rheum Dis
- ISSN
- 0003-4967
- eISSN
- 1468-2060
- Language
- English
- Date published
- 04/2015
- Academic Unit
- Nursing; Physical Therapy and Rehabilitation Science
- Record Identifier
- 9984046812002771
Metrics
17 Record Views