Sensitivity of Quantified Intracranial Aneurysm Geometry to Imaging Modality

Manasi Ramachandran; Rohini Retarekar; Robert E Harbaugh; David Hasan; Bruno Policeni; Robert Rosenwasser; Christopher Ogilvy; Madhavan L Raghavan

doi:10.1007/s13239-013-0119-9

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Sensitivity of Quantified Intracranial Aneurysm Geometry to Imaging Modality

Journal article

Open access

Peer reviewed

Sensitivity of Quantified Intracranial Aneurysm Geometry to Imaging Modality

Manasi Ramachandran, Rohini Retarekar, Robert E Harbaugh, David Hasan, Bruno Policeni, Robert Rosenwasser, Christopher Ogilvy and Madhavan L Raghavan

Cardiovascular engineering and technology, Vol.4(1), pp.75-86

03/2013

DOI: 10.1007/s13239-013-0119-9

PMCID: PMC3799891

PMID: 24151529

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Abstract

The objective of this study is to assess the sensitivity of intracranial aneurysm geometry to the modality of imaging. Four imaging modalities—3D rotational angiography (3DRA), computed tomography angiography (CTA), contrast enhanced magnetic resonance angiography (CE-MRA), and time-of-flight magnetic resonance angiography (TOF-MRA)—were assessed using data from a flow phantom and human subjects. A silicone flow phantom of the head and neck arteries with a 10 mm ACOM aneurysm was imaged using all four modalities under steady flow conditions. Three human subjects with mid to large sized intracranial aneurysm who had a 3DRA scan and one of CTA, CE-MRA, or TOF-MRA performed within a day were also studied. The aneurysm and contiguous vasculature were segmented for all available scans and geometric measures of their size (5 indices) and shape (6 indices) were estimated and compared. Visually, the size and shape of segmented 3D models of the aneurysms were similar across scan modalities for both the human subjects and the flow phantom. Consequently, the computed indices were consistent across modalities in the key morphometric indices. In conclusion, quantified indices of 3D geometry of the mid to large sized intracranial aneurysms investigated in this small study population are not sensitive to scanning modality.

Cerebral vasculature phantom

3D reconstruction

Multimodality imaging

Aneurysm size and shape indices

Details

Title: Subtitle: Sensitivity of Quantified Intracranial Aneurysm Geometry to Imaging Modality
Creators: Manasi Ramachandran - Department of Biomedical Engineering, University of Iowa, Iowa City, IA 52242, USA
Rohini Retarekar - Department of Biomedical Engineering, University of Iowa, Iowa City, IA 52242, USA
Robert E Harbaugh - Department of Neurosurgery, University of Iowa, Iowa City, IA, USA
David Hasan - Department of Neurosurgery, Penn State Milton S. Hershey Medical Center, Penn State University, Hershey, PA, USA
Bruno Policeni - Department of Neuroradiology, University of Iowa, Iowa City, IA, USA
Robert Rosenwasser - Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Christopher Ogilvy - Department of Neurological Surgery Jefferson University Hospital, Thomas Jefferson University, Philadelphia, PA, USA
Madhavan L Raghavan - Department of Biomedical Engineering, University of Iowa, Iowa City, IA 52242, USA
Resource Type: Journal article
Publication Details: Cardiovascular engineering and technology, Vol.4(1), pp.75-86
DOI: 10.1007/s13239-013-0119-9
PMID: 24151529
PMCID: PMC3799891
NLM abbreviation: Cardiovasc Eng Technol
ISSN: 1869-408X
eISSN: 1869-4098
Grant note: R01 HL083475 || HL / National Heart, Lung, and Blood Institute : NHLBI
Language: English
Date published: 03/2013
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Oral Pathology, Radiology and Medicine; Neurosurgery; Otolaryngology
Record Identifier: 9984040016102771

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