Journal article
Sensitivity to interstimulus interval due to calcium interactions in the Purkinje cell spines
Neurocomputing (Amsterdam), Vol.44, pp.13-18
06/01/2002
DOI: 10.1016/S0925-2312(02)00361-2
Abstract
Pairing specific LTD (PSD) is produced by paired parallel fiber (PF) and climbing fiber (CF) stimulation and requires Ca
2+ elevation. CF or PF activation cause Ca
2+ increase through voltage dependent channels and IP3 induced Ca
2+ release, respectively. We developed a model of Ca
2+ dynamics in Purkinje cell spines to investigate why paired PF–CF activation is necessary for PSD. Simulations show a supralinear increase of the Ca
2+ signal if the CF input occurs in a restricted time interval following the PF input. Ca
2+ buffers significantly contribute to this phenomenon. This mechanism may be involved in the requirement of temporal specificity in classical conditioning.
Details
- Title: Subtitle
- Sensitivity to interstimulus interval due to calcium interactions in the Purkinje cell spines
- Creators
- Jeanette Hellgren KotaleskiKim T. Blackwell
- Resource Type
- Journal article
- Publication Details
- Neurocomputing (Amsterdam), Vol.44, pp.13-18
- DOI
- 10.1016/S0925-2312(02)00361-2
- ISSN
- 0925-2312
- eISSN
- 1872-8286
- Publisher
- Elsevier B.V
- Language
- English
- Date published
- 06/01/2002
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Iowa Neuroscience Institute
- Record Identifier
- 9984446527202771
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