Sensitization of aortic and cardiac baroreceptors by arginine vasopressin in mammals

F. M ABBOUD; P. E AYLWARD; J. S FLORAS; B. N GUPTA

doi:10.1113/jphysiol.1986.sp016185

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Sensitization of aortic and cardiac baroreceptors by arginine vasopressin in mammals

Journal article

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Sensitization of aortic and cardiac baroreceptors by arginine vasopressin in mammals

F. M ABBOUD, P. E AYLWARD, J. S FLORAS and B. N GUPTA

The Journal of physiology, Vol.377(1), pp.251-265

1986

DOI: 10.1113/jphysiol.1986.sp016185

PMCID: PMC1182831

PMID: 3795090

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Abstract

Vasopressin facilitates the baroreflex control of the circulation. The peptide may act at several sites to augment the baroreflex. In this study we examined the effect of vasopressin on aortic baroreceptors in anaesthetized rabbits and on left ventricular mechanoreceptors in anaesthetized cats. Vasopressin (16 mu./kg. min) did not change resting nerve discharge in single fibres from aortic baroreceptors. Vasopressin (16 mu./kg. min) significantly enhanced the response of single aortic nerve fibre discharge to elevation in arterial pressure. The slope relating nerve activity to mean arterial pressure increased from 0.24 +/- 0.05 (mean +/- S.E. of mean) to 0.50 +/- 0.16 impulses/cardiac cycle. mmHg (P less than 0.05) in ten aortic medullated fibres and from 0.06 +/- 0.03 to 0.18 +/- 0.04 impulses/cardiac cycle. mmHg (P less than 0.05) in three non-medullated fibres. Vasopressin (16 mu./kg. min) did not change resting nerve discharge in single fibres from left ventricular mechanoreceptors. Vasopressin (16 mu./kg. min) significantly enhanced the response of single nerve fibre discharge from left ventricular mechanoreceptors in response to elevation of left ventricular end-diastolic pressure. The slope relating nerve activity to left ventricular end-diastolic pressure increased from 0.24 +/- 0.07 to 0.32 +/- 0.07 impulses/cardiac cycle. mmHg (P less than 0.05) in six medullated fibres and from 0.10 +/- 0.01 to 0.15 +/- 0.02 impulses/cardiac cycle. mmHg (P less than 0.05) in four non-medullated fibres. These data show that vasopressin sensitizes high and low pressure baroreceptors and suggest a mechanism by which vasopressin may facilitate the baroreflex control of the circulation.

Fundamental and applied biological sciences. Psychology

Cardiorespiratory control. Arterial mecano- and chemoreceptor

Biological and medical sciences

Vertebrates: respiratory system

Details

Title: Subtitle: Sensitization of aortic and cardiac baroreceptors by arginine vasopressin in mammals
Creators: F. M ABBOUD - Univ. Iowa, coll. medicine, Iowa City IA 52242, United States
P. E AYLWARD - Univ. Iowa, coll. medicine, Iowa City IA 52242, United States
J. S FLORAS - Univ. Iowa, coll. medicine, Iowa City IA 52242, United States
B. N GUPTA - Univ. Iowa, coll. medicine, Iowa City IA 52242, United States
Resource Type: Journal article
Publication Details: The Journal of physiology, Vol.377(1), pp.251-265
DOI: 10.1113/jphysiol.1986.sp016185
PMID: 3795090
PMCID: PMC1182831
NLM abbreviation: J Physiol
ISSN: 0022-3751
eISSN: 1469-7793
Publisher: Blackwell; Oxford
Language: English
Date published: 1986
Academic Unit: Molecular Physiology and Biophysics; Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
Record Identifier: 9984025670402771

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