Sensorimotor Oscillatory Phase–Power Interaction Gates Resting Human Corticospinal Output

Sara J Hussain; Leonardo Claudino; Marlene Bönstrup; Gina Norato; Gabriel Cruciani; Ryan Thompson; Christoph Zrenner; Ulf Ziemann; Ethan Buch; Leonardo G Cohen

doi:10.1093/cercor/bhy255

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Sensorimotor Oscillatory Phase–Power Interaction Gates Resting Human Corticospinal Output

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Sensorimotor Oscillatory Phase–Power Interaction Gates Resting Human Corticospinal Output

Sara J Hussain, Leonardo Claudino, Marlene Bönstrup, Gina Norato, Gabriel Cruciani, Ryan Thompson, Christoph Zrenner, Ulf Ziemann, Ethan Buch and Leonardo G Cohen

Cerebral cortex (New York, N.Y. 1991), Vol.29(9), pp.3766-3777

08/14/2019

DOI: 10.1093/cercor/bhy255

PMCID: PMC6686752

PMID: 30496352

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Abstract

Oscillatory activity within sensorimotor networks is characterized by time-varying changes in phase and power. The influence of interactions between sensorimotor oscillatory phase and power on human motor function, like corticospinal output, is unknown. We addressed this gap in knowledge by delivering transcranial magnetic stimulation (TMS) to the human motor cortex during electroencephalography recordings in 20 healthy participants. Motor evoked potentials, a measure of corticospinal excitability, were categorized offline based on the mu (8–12 Hz) and beta (13–30 Hz) oscillatory phase and power at the time of TMS. Phase-dependency of corticospinal excitability was evaluated across a continuous range of power levels using trial-by-trial linear mixed-effects models. For mu, there was no effect of PHASE or POWER ( P > 0.51), but a significant PHASE × POWER interaction ( P = 0.002). The direction of phase-dependency reversed with changing mu power levels: corticospinal output was higher during mu troughs versus peaks when mu power was high while the opposite was true when mu power was low. A similar PHASE × POWER interaction was not present for beta oscillations ( P > 0.11). We conclude that the interaction between sensorimotor oscillatory phase and power gates human corticospinal output to an extent unexplained by sensorimotor oscillatory phase or power alone.

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Title: Subtitle: Sensorimotor Oscillatory Phase–Power Interaction Gates Resting Human Corticospinal Output
Creators: Sara J Hussain - National Institute of Neurological Disorders and Stroke
Leonardo Claudino - National Institutes of Health
Marlene Bönstrup - National Institute of Neurological Disorders and Stroke
Gina Norato - National Institute of Neurological Disorders and Stroke
Gabriel Cruciani - National Institute of Neurological Disorders and Stroke
Ryan Thompson - National Institute of Neurological Disorders and Stroke
Christoph Zrenner - Hertie Institute for Clinical Brain Research
Ulf Ziemann - Hertie Institute for Clinical Brain Research
Ethan Buch - National Institute of Neurological Disorders and Stroke
Leonardo G Cohen - National Institutes of Health
Resource Type: Journal article
Publication Details: Cerebral cortex (New York, N.Y. 1991), Vol.29(9), pp.3766-3777
DOI: 10.1093/cercor/bhy255
PMID: 30496352
PMCID: PMC6686752
NLM abbreviation: Cereb Cortex
ISSN: 1047-3211
eISSN: 1460-2199
Publisher: Oxford University Press
Number of pages: 12
Grant note: ; ; ; ; ;
Language: English
Date published: 08/14/2019
Academic Unit: Health, Sport, and Human Physiology
Record Identifier: 9984948144602771

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