Journal article
Sensory- and memory-mediated olfactory dysfunction in Huntington's disease
Journal of the International Neuropsychological Society, Vol.1(3), pp.281-290
05/1995
DOI: 10.1017/S1355617700000278
PMID: 9375222
Abstract
Neuropathology in Huntington's disease (HD) known to project to areas that process olfactory information raises the questions of which olfactory function, if any, is most affected in HD, and how to explain such dysfunction in terms of olfactory sensitivity and cognition. These questions were studied by comparing HD patients and controls (matched for age, gender, and education) on absolute detection, intensity discrimination, quality discrimination, short-term recognition memory, and lexical- and picture-based identification for odor. Taste or vision were used as comparison modalities. The results suggest that whereas odor-recognition memory is not affected in patients with HD, these patients have impaired olfactory functioning with respect to absolute detection, intensity discrimination, quality discrimination, and identification. The three latter impairments were significantly explained by poor detection sensitivity. Odor identification was the function most affected. (JINS, 1995, I, 281–290.)
Details
- Title: Subtitle
- Sensory- and memory-mediated olfactory dysfunction in Huntington's disease
- Creators
- Steven Nordin - 1University of California Medical Center, San Diego, CA 92103Jane S Paulsen - 3San Diego Department of Veterans Affairs Medical Center, San Diego, CA 92161Claire Murphy - 1University of California Medical Center, San Diego, CA 92103
- Resource Type
- Journal article
- Publication Details
- Journal of the International Neuropsychological Society, Vol.1(3), pp.281-290
- Publisher
- Cambridge University Press
- DOI
- 10.1017/S1355617700000278
- PMID
- 9375222
- ISSN
- 1355-6177
- eISSN
- 1469-7661
- Number of pages
- 10
- Language
- English
- Date published
- 05/1995
- Academic Unit
- Psychiatry; Psychological and Brain Sciences
- Record Identifier
- 9984083204302771
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