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Sensory Coding of Limb Kinematics in Motor Cortex across a Key Developmental Transition
Journal article   Open access   Peer reviewed

Sensory Coding of Limb Kinematics in Motor Cortex across a Key Developmental Transition

Ryan M Glanz, James C Dooley, Greta Sokoloff and Mark S Blumberg
The Journal of neuroscience, Vol.41(32), pp.6905-6918
08/11/2021
DOI: 10.1523/JNEUROSCI.0921-21.2021
PMCID: PMC8360693
PMID: 34281990
url
https://doi.org/10.1523/JNEUROSCI.0921-21.2021View
Published (Version of record) Open Access

Abstract

Primary motor cortex (M1) undergoes protracted development in mammals, functioning initially as a sensory structure. Throughout the first postnatal week in rats, M1 is strongly activated by self-generated forelimb movements-especially by the twitches that occur during active sleep. Here, we quantify the kinematic features of forelimb movements to reveal receptive field properties of individual units within the forelimb region of M1. At postnatal day 8 (P8), nearly all units were strongly modulated by movement amplitude, especially during active sleep. By P12, only a minority of units continued to exhibit amplitude tuning, regardless of behavioral state. At both ages, movement direction also modulated M1 activity, though to a lesser extent. Finally, at P12, M1 population-level activity became more sparse and decorrelated, along with a substantial alteration in the statistical distribution of M1 responses to limb movements. These findings reveal a transition toward a more and rich of movement before M1 its motor
 Life Sciences & Biomedicine Neurosciences Neurosciences & Neurology Science & Technology

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