Sensory Nerve Innervation of Epineurial Arterioles of the Sciatic Nerve Containing Calcitonin Gene–Related Peptide: Effect of Streptozotocin-Induced Diabetes

M. A Yorek; L. J Coppey; J. S Gellett; E. P Davidson

doi:10.1080/15438600490486732

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Sensory Nerve Innervation of Epineurial Arterioles of the Sciatic Nerve Containing Calcitonin Gene–Related Peptide: Effect of Streptozotocin-Induced Diabetes

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Sensory Nerve Innervation of Epineurial Arterioles of the Sciatic Nerve Containing Calcitonin Gene–Related Peptide: Effect of Streptozotocin-Induced Diabetes

M. A Yorek, L. J Coppey, J. S Gellett and E. P Davidson

Experimental diabesity research, Vol.5(3), pp.187-193

2004

DOI: 10.1080/15438600490486732

PMCID: PMC2478627

PMID: 15512786

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Abstract

The authors have determined that epineurial arterioles of the sciatic nerve are innervated by nonadrenergic, noncholinergic nerves that contribute to the regulation of vasodilation. Using immunohistochemistry, the authors determined that nerves innervating epineurial arterioles contain the neuropeptide calcitonin gene–related peptide (CGRP). Using streptozotocin-induced diabetic rats, the authors demonstrated that CGRP content in sensory nerves innervating epineurial arterioles and vasodilation in response to exogenous CGRP was decreased. In summary, epineurial arterioles of the sciatic nerve are innervated by sensory nerves containing the neuropeptide CGRP. The diabetes-like condition induced by streptozotocin reduces the content of CGRP in these nerves and exogenous CGRPmediated vasodilation. CGRP is likely an important regulator of vascular tone and compromising its function could contribute to nerve ischemia and diabetic neuropathy.

Details

Title: Subtitle: Sensory Nerve Innervation of Epineurial Arterioles of the Sciatic Nerve Containing Calcitonin Gene–Related Peptide: Effect of Streptozotocin-Induced Diabetes
Creators: M. A Yorek - Department of Internal Medicine, University of Iowa and Veterans Affairs Medical Center, Iowa City, Iowa 52246, USA
L. J Coppey - Department of Internal Medicine, University of Iowa and Veterans Affairs Medical Center, Iowa City, Iowa 52246, USA
J. S Gellett - Department of Internal Medicine, University of Iowa and Veterans Affairs Medical Center, Iowa City, Iowa 52246, USA
E. P Davidson - Department of Internal Medicine, University of Iowa and Veterans Affairs Medical Center, Iowa City, Iowa 52246, USA
Resource Type: Journal article
Publication Details: Experimental diabesity research, Vol.5(3), pp.187-193
DOI: 10.1080/15438600490486732
PMID: 15512786
PMCID: PMC2478627
NLM abbreviation: Exp Diabesity Res
ISSN: 1543-8600
eISSN: 1543-8619
Language: English
Date published: 2004
Academic Unit: Fraternal Order of Eagles Diabetes Research Center; Endocrinology and Metabolism; Internal Medicine
Record Identifier: 9984094621402771

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