Journal article
Separating the effect of reward from corrective feedback during learning in patients with Parkinson's disease
Cognitive, affective, & behavioral neuroscience, Vol.17(3), pp.678-695
06/2017
DOI: 10.3758/s13415-017-0505-0
PMID: 28397140
Abstract
Parkinson's disease (PD) is associated with procedural learning deficits. Nonetheless, studies have demonstrated that reward-related learning is comparable between patients with PD and controls (Bódi et al., Brain, 132(9), 2385-2395, 2009; Frank, Seeberger, & O'Reilly, Science, 306(5703), 1940-1943, 2004; Palminteri et al., Proceedings of the National Academy of Sciences of the United States of America, 106(45), 19179-19184, 2009). However, because these studies do not separate the effect of reward from the effect of practice, it is difficult to determine whether the effect of reward on learning is distinct from the effect of corrective feedback on learning. Thus, it is unknown whether these group differences in learning are due to reward processing or learning in general. Here, we compared the performance of medicated PD patients to demographically matched healthy controls (HCs) on a task where the effect of reward can be examined separately from the effect of practice. We found that patients with PD showed significantly less reward-related learning improvements compared to HCs. In addition, stronger learning of rewarded associations over unrewarded associations was significantly correlated with smaller skin-conductance responses for HCs but not PD patients. These results demonstrate that when separating the effect of reward from the effect of corrective feedback, PD patients do not benefit from reward.
Details
- Title: Subtitle
- Separating the effect of reward from corrective feedback during learning in patients with Parkinson's disease
- Creators
- Michael Freedberg - Henry M. Jackson Foundation for the Advancement of Military Medicine, 9000 Rockville Pike, 10 Center Drive, Rm 7D49A, Bethesda, MD, 20814, USA. michael.freedberg@nih.govJonathan Schacherer - Department of Psychological and Brain Sciences, University of Iowa, Iowa City, IA, 52242, USAKuan-Hua Chen - Institute of Personality and Social Research, University of California, Berkeley, CA, 94720, USAErgun Y Uc - Neurology Service, Veterans Affairs Medical Center, Iowa City, IA, 52242, USANandakumar S Narayanan - Aging Mind, Brain Initiative, Carver College of Medicine, Iowa City, 52242, IA, USAEliot Hazeltine - Department of Psychological and Brain Sciences, University of Iowa, Iowa City, IA, 52242, USA
- Resource Type
- Journal article
- Publication Details
- Cognitive, affective, & behavioral neuroscience, Vol.17(3), pp.678-695
- Publisher
- United States
- DOI
- 10.3758/s13415-017-0505-0
- PMID
- 28397140
- ISSN
- 1530-7026
- eISSN
- 1531-135X
- Grant note
- DOI: 10.13039/100000026, name: National Institute on Drug Abuse, award: 5R03DA031583-02
- Language
- English
- Date published
- 06/2017
- Academic Unit
- Neurology; Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984020650902771
Metrics
12 Record Views