Journal article
Separation of cyclotron-produced Sc-44 from a natural calcium target using a dipentyl pentylphosphonate functionalized extraction resin
Applied radiation and isotopes, Vol.95, pp.23-29
01/01/2015
DOI: 10.1016/j.apradiso.2014.09.020
PMCID: PMC4390433
PMID: 25464172
Abstract
Significant interest in Sc-44 as a radioactive synthon to label small molecules for positron emission tomography (PET) imaging has been recently observed. Despite the efforts of several research groups, the ideal Sc-44 production and separation method remains elusive. Herein, we propose a novel separation method to obtain Sc-44 from the proton irradiation of calcium targets based on extraction chromatography, which promises to greatly simplify current production methodologies. Using the commercially available Uranium and Tetravalent Actinides (UTEVA) extraction resin we were able to rapidly ( < 20 min) recover >80% of the activity generated at end of bombardment (EoB) in small similar to 1 M HCl fractions (400 mu L). The chemical purity of the Sc-44 eluates was evaluated through chelation with DOTA and DTPA, and by trace metal analysis using microwave induced plasma atomic emission spectrometry. The distribution coefficients (K-d) of Sc(III) and Ca(II) in UTEVA were determined in HCI medium in a range of concentrations from zero to 12.1 M. The Sc-44 obtained with our method proved to be suitable for the direct labeling of small biomolecules for PET imaging, with excellent specific activities and radiochemical purity. (C) 2014 Elsevier Ltd. All rights reserved.
Details
- Title: Subtitle
- Separation of cyclotron-produced Sc-44 from a natural calcium target using a dipentyl pentylphosphonate functionalized extraction resin
- Creators
- H. F. Valdovinos - University of Wisconsin–MadisonR. Hernandez - University of Wisconsin–MadisonT. E. Barnhart - University of Wisconsin–MadisonS. Graves - University of Wisconsin–MadisonW. Cai - University of Wisconsin–MadisonR. J. Nickles - University of Wisconsin–Madison
- Resource Type
- Journal article
- Publication Details
- Applied radiation and isotopes, Vol.95, pp.23-29
- DOI
- 10.1016/j.apradiso.2014.09.020
- PMID
- 25464172
- PMCID
- PMC4390433
- NLM abbreviation
- Appl Radiat Isot
- ISSN
- 0969-8043
- eISSN
- 1872-9800
- Publisher
- Elsevier
- Number of pages
- 7
- Grant note
- T32GM008349 / NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS) DOE-SC0008384 / US Department of Energy; United States Department of Energy (DOE) T32CA009206 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) Advanced Opportunity Fellowship, Science and Medicine Graduate Research Scholars (SciMed GRS) Program at UW-Madison DGE-1256259 / US National Science Foundation; National Science Foundation (NSF) 5T32GM08349 / US National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Language
- English
- Date published
- 01/01/2015
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Radiation Oncology
- Record Identifier
- 9984383286402771
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