Sepsis-Induced T Cell Immunoparalysis: The Ins and Outs of Impaired T Cell Immunity

Isaac J Jensen; Frances V Sjaastad; Thomas S Griffith; Vladimir P Badovinac

doi:10.4049/jimmunol.1701618

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Sepsis-Induced T Cell Immunoparalysis: The Ins and Outs of Impaired T Cell Immunity

Journal article

Peer reviewed

Sepsis-Induced T Cell Immunoparalysis: The Ins and Outs of Impaired T Cell Immunity

Isaac J Jensen, Frances V Sjaastad, Thomas S Griffith and Vladimir P Badovinac

The Journal of immunology (1950), Vol.200(5), pp.1543-1553

03/01/2018

DOI: 10.4049/jimmunol.1701618

PMCID: PMC5826615

PMID: 29463691

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Abstract

Sepsis results in a deluge of pro- and anti-inflammatory cytokines, leading to lymphopenia and chronic immunoparalysis. Sepsis-induced long-lasting immunoparalysis is defined, in part, by impaired CD4 and CD8 αβ T cell responses in the postseptic environment. The dysfunction in T cell immunity affects naive, effector, and memory T cells and is not restricted to classical αβ T cells. Although sepsis-induced severe and transient lymphopenia is a contributory factor to diminished T cell immunity, T cell-intrinsic and -extrinsic factors/mechanisms also contribute to impaired T cell function. In this review, we summarize the current knowledge of how sepsis quantitatively and qualitatively impairs CD4 and CD8 T cell immunity of classical and nonclassical T cell subsets and discuss current therapeutic approaches being developed to boost the recovery of T cell immunity postsepsis induction.

Animals

Cytokines - immunology

Humans

Inflammation - immunology

Lymphopenia - immunology

Sepsis - immunology

T-Lymphocytes - immunology

Details

Title: Subtitle: Sepsis-Induced T Cell Immunoparalysis: The Ins and Outs of Impaired T Cell Immunity
Creators: Isaac J Jensen - University of Iowa
Frances V Sjaastad - University of Minnesota
Thomas S Griffith - University of Minnesota
Vladimir P Badovinac - University of Iowa
Resource Type: Journal article
Publication Details: The Journal of immunology (1950), Vol.200(5), pp.1543-1553
DOI: 10.4049/jimmunol.1701618
PMID: 29463691
PMCID: PMC5826615
NLM abbreviation: J Immunol
ISSN: 0022-1767
eISSN: 1550-6606
Grant note: I01 BX001324 / BLRD VA T32 AI007511 / NIAID NIH HHS R01 AI114543 / NIAID NIH HHS R21 AI119160 / NIAID NIH HHS R01 AI083286 / NIAID NIH HHS T32 AI007485 / NIAID NIH HHS R01 GM113961 / NIGMS NIH HHS T32 CA009138 / NCI NIH HHS P30 CA086862 / NCI NIH HHS R01 GM115462 / NIGMS NIH HHS
Language: English
Date published: 03/01/2018
Academic Unit: Microbiology and Immunology; Pathology
Record Identifier: 9984181073102771

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