Journal article
Sepsis and multiple sclerosis: Causative links and outcomes
Immunology letters, Vol.238, pp.40-46
10/2021
DOI: 10.1016/j.imlet.2021.07.008
PMID: 34320384
Abstract
•Potential interplay between sepsis and multiple sclerosis (MS) is reviewed.•Immunological mechanism(s) governing sepsis/MS interactions are proposed.•The role of gut microbiota influencing the sepsis/MS interaction is discussed.
Sepsis is a life-threatening condition characterized by an acute cytokine storm followed by prolonged dysfunction of the immune system in the survivors. Post-septic lymphopenia and functional deficits of the remaining immune cells lead to increased susceptibility to secondary infections and other morbid conditions causing late death in the patients. This state of post-septic immunoparalysis may also influence disorders stemming from inappropriate or overactive immune responses, such as autoimmune and immunoinflammatory diseases, including multiple sclerosis. In addition, ongoing autoimmunity likely influences the susceptibility to and outcome of sepsis. This review article addresses the bidirectional relationship between sepsis and multiple sclerosis, with a focus on the immunologic mechanisms of the interaction and potential directions for future studies.
Details
- Title: Subtitle
- Sepsis and multiple sclerosis: Causative links and outcomes
- Creators
- Đorđe Miljković - University of BelgradeSuzana Stanisavljević - University of BelgradeIsaac J Jensen - University of IowaThomas S Griffith - University of MinnesotaVladimir P Badovinac - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Immunology letters, Vol.238, pp.40-46
- DOI
- 10.1016/j.imlet.2021.07.008
- PMID
- 34320384
- NLM abbreviation
- Immunol Lett
- ISSN
- 0165-2478
- eISSN
- 1879-0542
- Publisher
- Elsevier B.V
- Grant note
- DOI: 10.13039/100000002, name: National Institutes of Health, award: R01AI114543, R01GM115462, R21AI147064, R21AI151183, R35GM134880, R35GM140881, T32AI007485, T32AI007511; DOI: 10.13039/100000738, name: US Department of Veterans Affairs, award: I01BX001324; DOI: 10.13039/100007217, name: Health Services Research and Development; DOI: 10.13039/501100004564, name: Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja; DOI: 10.13039/501100016047, name: Science Fund of the Republic of Serbia, award: 6409283
- Language
- English
- Date published
- 10/2021
- Academic Unit
- Microbiology and Immunology; Pathology
- Record Identifier
- 9984181068102771
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