Journal article
Sepsis-induced changes in differentiation, maintenance, and function of memory CD8 T cell subsets
Frontiers in immunology, Vol.14, 1130009
01/23/2023
DOI: 10.3389/fimmu.2023.1130009
PMCID: PMC9899844
PMID: 36756117
Abstract
Formation of long-lasting memory lymphocytes is one of the foundational characteristics of adaptive immunity and the basis of many vaccination strategies. Following the rapid expansion and contraction of effector CD8 T cells, the surviving antigen (Ag)-specific cells give rise to the memory CD8 T cells that persist for a long time and are phenotypically and functionally distinct from their naïve counterparts. Significant heterogeneity exists within the memory CD8 T cell pool, as different subsets display distinct tissue localization preferences, cytotoxic ability, and proliferative capacity, but all memory CD8 T cells are equipped to mount an enhanced immune response upon Ag re-encounter. Memory CD8 T cells demonstrate numerical stability under homeostatic conditions, but sepsis causes a significant decline in the number of memory CD8 T cells and diminishes their Ag-dependent and -independent functions. Sepsis also rewires the transcriptional profile of memory CD8 T cells, which profoundly impacts memory CD8 T cell differentiation and, ultimately, the protective capacity of memory CD8 T cells upon subsequent stimulation. This review delves into different aspects of memory CD8 T cell subsets as well as the immediate and long-term impact of sepsis on memory CD8 T cell biology.
Details
- Title: Subtitle
- Sepsis-induced changes in differentiation, maintenance, and function of memory CD8 T cell subsets
- Creators
- Mohammad Heidarian - University of IowaThomas S. GriffithVladimir P. Badovinac
- Resource Type
- Journal article
- Publication Details
- Frontiers in immunology, Vol.14, 1130009
- DOI
- 10.3389/fimmu.2023.1130009
- PMID
- 36756117
- PMCID
- PMC9899844
- NLM abbreviation
- Front Immunol
- ISSN
- 1664-3224
- eISSN
- 1664-3224
- Grant note
- DOI: 10.13039/100000057, name: National Institute of General Medical Sciences; DOI: 10.13039/100000060, name: National Institute of Allergy and Infectious Diseases; DOI: 10.13039/100000057, name: National Institute of General Medical Sciences
- Language
- English
- Date published
- 01/23/2023
- Academic Unit
- Pathology
- Record Identifier
- 9984362760202771
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