Sequence Analysis of the Staphylococcus aureus srrAB Loci Reveals that Truncation of srrA Affects Growth and Virulence Factor Expression

Alexa A Pragman; Lisa Herron-Olson; Laura C Case; Sara M Vetter; Evan E Henke; Vivek Kapur; Patrick M Schlievert

doi:10.1128/JB.00547-07

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Sequence Analysis of the Staphylococcus aureus srrAB Loci Reveals that Truncation of srrA Affects Growth and Virulence Factor Expression

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Sequence Analysis of the Staphylococcus aureus srrAB Loci Reveals that Truncation of srrA Affects Growth and Virulence Factor Expression

Alexa A Pragman, Lisa Herron-Olson, Laura C Case, Sara M Vetter, Evan E Henke, Vivek Kapur and Patrick M Schlievert

Journal of bacteriology, Vol.189(20), pp.7515-7519

10/2007

DOI: 10.1128/JB.00547-07

PMCID: PMC2168425

PMID: 17693503

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Abstract

The SrrAB system regulates metabolism and virulence factors in Staphylococcus aureus . We sequenced the srrAB loci of 21 isolates and performed a phylogenetic analysis. Vaginal and bovine isolates clustered together, while skin isolates were genetically diverse. Few nucleotide polymorphisms were observed, and most were synonymous. Two strains (N2 and N19) with N-terminal truncations in SrrA displayed defects in growth and abnormally upregulated virulence factor expression under low-oxygen conditions.

Molecular Biology of Pathogens

Details

Title: Subtitle: Sequence Analysis of the Staphylococcus aureus srrAB Loci Reveals that Truncation of srrA Affects Growth and Virulence Factor Expression
Creators: Alexa A Pragman - Department of Microbiology, University of Minnesota Medical School, Minneapolis, Minnesota 55455
Lisa Herron-Olson - Department of Microbiology, University of Minnesota Medical School, Minneapolis, Minnesota 55455
Laura C Case - Department of Microbiology, University of Minnesota Medical School, Minneapolis, Minnesota 55455
Sara M Vetter - Department of Microbiology, University of Minnesota Medical School, Minneapolis, Minnesota 55455
Evan E Henke - Department of Microbiology, University of Minnesota Medical School, Minneapolis, Minnesota 55455
Vivek Kapur - Department of Microbiology, University of Minnesota Medical School, Minneapolis, Minnesota 55455
Patrick M Schlievert - Department of Microbiology, University of Minnesota Medical School, Minneapolis, Minnesota 55455
Resource Type: Journal article
Publication Details: Journal of bacteriology, Vol.189(20), pp.7515-7519
DOI: 10.1128/JB.00547-07
PMID: 17693503
PMCID: PMC2168425
NLM abbreviation: J Bacteriol
ISSN: 0021-9193
eISSN: 1098-5530
Publisher: American Society for Microbiology (ASM)
Language: English
Date published: 10/2007
Academic Unit: Microbiology and Immunology; Internal Medicine
Record Identifier: 9984001143402771

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