Journal article
Sequence and Expression of mRNAs Encoding the α1 and α2 Subunits of a DHP-Sensitive Calcium Channel
Science (American Association for the Advancement of Science), Vol.241(4873), pp.1661-1664
09/23/1988
DOI: 10.1126/science.2458626
PMID: 2458626
Abstract
Complementary DNAs were isolated and used to deduce the primary structures of the α1 and α2 subunits of the dihydropyridine-sensitive, voltage-dependent calcium channel from rabbit skeletal muscle. The α1 subunit, which contains putative binding sites for calcium antagonists, is a hydrophobic protein with a sequence that is consistent with multiple transmembrane domains and shows structural and sequence homology with other voltage-dependent ion channels. In contrast, the α2 subunit is a hydrophilic protein without homology to other known protein sequences. Nucleic acid hybridization studies suggest that the α1 and α2 subunit mRNAs are expressed differentially in a tissue-specific manner and that there is a family of genes encoding additional calcium channel subtypes.
Details
- Title: Subtitle
- Sequence and Expression of mRNAs Encoding the α1 and α2 Subunits of a DHP-Sensitive Calcium Channel
- Creators
- Steven B Ellis - Salk Institute Biotechnology/Industrial Associates, Inc., La Jolla, CA 92037Mark E Williams - Salk Institute Biotechnology/Industrial Associates, Inc., La Jolla, CA 92037Nancy R Ways - Salk Institute Biotechnology/Industrial Associates, Inc., La Jolla, CA 92037Robert Brenner - Salk Institute Biotechnology/Industrial Associates, Inc., La Jolla, CA 92037Alan H Sharp - Department of Physiology and Biophysics, University of Iowa, Iowa City, IA 52242Albert T Leung - Department of Physiology and Biophysics, University of Iowa, Iowa City, IA 52242Kevin P Campbell - Department of Physiology and Biophysics, University of Iowa, Iowa City, IA 52242Edward McKenna - Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH 45267Walter J Koch - Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH 45267Anna Hui - Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH 45267Arnold Schwartz - Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH 45267Michael M Harpold - Salk Institute Biotechnology/Industrial Associates, Inc., La Jolla, CA 92037
- Resource Type
- Journal article
- Publication Details
- Science (American Association for the Advancement of Science), Vol.241(4873), pp.1661-1664
- DOI
- 10.1126/science.2458626
- PMID
- 2458626
- ISSN
- 0036-8075
- eISSN
- 1095-9203
- Language
- English
- Date published
- 09/23/1988
- Academic Unit
- Neurology; Molecular Physiology and Biophysics; Iowa Neuroscience Institute
- Record Identifier
- 9984068386302771
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