Journal article
Sequence and chromosomal assignment of human BAPX1, a bagpipe-related gene, to 4p16.1: A candidate gene for skeletal dysplasia
Genomics (San Diego, Calif.), Vol.45(2), pp.425-428
1997
DOI: 10.1006/geno.1997.4926
PMID: 9344671
Abstract
Homeobox-containing genes play an important role in both body axis determination and specific organ development. They have increasingly been found to be mutated in human birth defect disorders. Sequences of two bagpipe-related genes in the mouse, Nkx-3.1 and Nkx-3.2, have already been reported. Nkx-3.1 was isolated from the prostate, and its human homolog NKX-3.1 has also been described. Mouse Nkx-3.2, or bapx1, has also been isolated, and its expression in the visceral mesoderm and embryonic skeleton in the mouse has been described. We report here the human BAPX1 sequence and its localization to chromosome region 4p16.1 and suggest BAPX1 as a candidate for disorders of skeletal development that might map to 4p16.1.
Copyright 1997 Academic Press.
Details
- Title: Subtitle
- Sequence and chromosomal assignment of human BAPX1, a bagpipe-related gene, to 4p16.1: A candidate gene for skeletal dysplasia
- Creators
- K.-I YOSHIURA - Department of Pediatrics, The University of Iowa, Iowa City, Iowa 52242, United StatesJ. C MURRAY - Department of Pediatrics, The University of Iowa, Iowa City, Iowa 52242, United States
- Resource Type
- Journal article
- Publication Details
- Genomics (San Diego, Calif.), Vol.45(2), pp.425-428
- DOI
- 10.1006/geno.1997.4926
- PMID
- 9344671
- NLM abbreviation
- Genomics
- ISSN
- 0888-7543
- eISSN
- 1089-8646
- Publisher
- Elsevier; San Diego, CA
- Language
- English
- Date published
- 1997
- Academic Unit
- Anatomy and Cell Biology; Stead Family Department of Pediatrics; Epidemiology; Pediatric Dentistry; Craniofacial Anomalies Research Center; Dental Research
- Record Identifier
- 9984025358802771
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