Journal article
Sequence differentiation associated with an inversion on the neo-X chromosome of Drosophila americana
Genetics (Austin), Vol.165(3), pp.1317-1328
11/2003
PMCID: PMC1462813
PMID: 14668385
Abstract
Sex chromosomes originate from pairs of autosomes that acquire controlling genes in the sex-determining cascade. Universal mechanisms apparently influence the evolution of sex chromosomes, because this chromosomal pair is characteristically heteromorphic in a broad range of organisms. To examine the pattern of initial differentiation between sex chromosomes, sequence analyses were performed on a pair of newly formed sex chromosomes in Drosophila americana. This species has neo-sex chromosomes as a result of a centromeric fusion between the X chromosome and an autosome. Sequences were analyzed from the Alcohol dehydrogenase (Adh), big brain (bib), and timeless (tim) gene regions, which represent separate positions along this pair of neo-sex chromosomes. In the northwestern range of the species, the bib and Adh regions exhibit significant sequence differentiation for neo-X chromosomes relative to neo-Y chromosomes from the same geographic region and other chromosomal populations of D. americana. Furthermore, a nucleotide site defining a common haplotype in bib is shown to be associated with a paracentric inversion [In(4)ab] on the neo-X chromosome, and this inversion suppresses recombination between neo-X and neo-Y chromosomes. These observations are consistent with the inversion acting as a recombination modifier that suppresses exchange between these neo-sex chromosomes, as predicted by models of sex chromosome evolution.
Details
- Title: Subtitle
- Sequence differentiation associated with an inversion on the neo-X chromosome of Drosophila americana
- Creators
- Bryant F McAllister - Department of Biology, University of Texas, Arlington, Texas 76019, USA. bryant-mcallister@uiowa.edu
- Resource Type
- Journal article
- Publication Details
- Genetics (Austin), Vol.165(3), pp.1317-1328
- Publisher
- United States
- PMID
- 14668385
- PMCID
- PMC1462813
- ISSN
- 0016-6731
- eISSN
- 1943-2631
- Language
- English
- Date published
- 11/2003
- Academic Unit
- Biology
- Record Identifier
- 9983991963802771
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