Sequential Apparent Diffusion Coefficient for Assessment of Tumor Progression in Patients with Low-Grade Glioma

I E Chen; N Swinburne; N M Tsankova; M M Hefti; A Aggarwal; A H Doshi; A Hormigo; B N Delman; K Nael

doi:10.3174/ajnr.A5639

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Sequential Apparent Diffusion Coefficient for Assessment of Tumor Progression in Patients with Low-Grade Glioma

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Sequential Apparent Diffusion Coefficient for Assessment of Tumor Progression in Patients with Low-Grade Glioma

I E Chen, N Swinburne, N M Tsankova, M M Hefti, A Aggarwal, A H Doshi, A Hormigo, B N Delman and K Nael

American journal of neuroradiology : AJNR, Vol.39(6), pp.1039-1046

06/2018

DOI: 10.3174/ajnr.A5639

PMID: 29674411

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Abstract

Early and accurate identification of tumor progression in patients with low-grade gliomas is challenging. We aimed to assess the role of quantitative ADC analysis in the sequential follow-up of patients with low-grade gliomas as a potential imaging marker of tumor stability or progression. In this retrospective study, patients with a diagnosis of low-grade glioma with at least 12 months of imaging follow-up were retrospectively reviewed. Two neuroradiologists independently reviewed sequential MR imaging in each patient to determine tumor progression using the Response Assessment in Neuro-Oncology criteria. Normalized mean ADC (ADC ) and 10th percentile ADC (ADC ) values from FLAIR hyperintense tumor volume were calculated for each MR image and compared between patients with stable disease versus tumor progression using univariate analysis. The interval change of ADC values between sequential scans was used to differentiate stable disease from progression using the Fisher exact test. Twenty-eight of 69 patients who were evaluated met our inclusion criteria. Fifteen patients were classified as stable versus 13 patients as having progression based on consensus reads of MRIs and the Response Assessment in Neuro-Oncology criteria. The interval change of ADC values showed greater concordance with ultimate lesion disposition than quantitative ADC values at a single time point. The interval change in ADC matched the expected pattern in 12/13 patients with tumor progression (overall diagnostic accuracy of 86%, <.001). On average, the ADC interval change predicted progression 8 months before conventional MR imaging. The interval change of ADC values can be used to identify progression versus stability of low-grade gliomas with a diagnostic accuracy of 86% and before apparent radiologic progression on conventional MR imaging.

Details

Title: Subtitle: Sequential Apparent Diffusion Coefficient for Assessment of Tumor Progression in Patients with Low-Grade Glioma
Creators: I E Chen - From the Departments of Radiology (I.E.C., N.S., A.A., A.H.D., B.N.D., K.N.)
N Swinburne - From the Departments of Radiology (I.E.C., N.S., A.A., A.H.D., B.N.D., K.N.)
N M Tsankova - Pathology (N.M.T., M.M.H.)
M M Hefti - Pathology (N.M.T., M.M.H.)
A Aggarwal - From the Departments of Radiology (I.E.C., N.S., A.A., A.H.D., B.N.D., K.N.)
A H Doshi - From the Departments of Radiology (I.E.C., N.S., A.A., A.H.D., B.N.D., K.N.)
A Hormigo - Neurology (A.H.), Icahn School of Medicine at Mount Sinai, New York, New York
B N Delman - From the Departments of Radiology (I.E.C., N.S., A.A., A.H.D., B.N.D., K.N.)
K Nael - From the Departments of Radiology (I.E.C., N.S., A.A., A.H.D., B.N.D., K.N.) Kambiznael@gmail.com
Resource Type: Journal article
Publication Details: American journal of neuroradiology : AJNR, Vol.39(6), pp.1039-1046
DOI: 10.3174/ajnr.A5639
PMID: 29674411
NLM abbreviation: AJNR Am J Neuroradiol
ISSN: 0195-6108
eISSN: 1936-959X
Publisher: United States
Language: English
Date published: 06/2018
Academic Unit: Gastroenterology and Hepatology; Pathology; Iowa Neuroscience Institute; Internal Medicine
Record Identifier: 9984047710702771

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