Sequential cognitive skills in emphysema patients following lung volume reduction surgery: a 2-year longitudinal study

Elizabeth Kozora; Charles F Emery; Lening Zhang; Karin F Hoth; James Murphy; Barry Make; National Emphysema Treatment Trial Research Group

doi:10.1097/HCR.0b013e3182343bc8

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Sequential cognitive skills in emphysema patients following lung volume reduction surgery: a 2-year longitudinal study

Journal article

Peer reviewed

Sequential cognitive skills in emphysema patients following lung volume reduction surgery: a 2-year longitudinal study

Elizabeth Kozora, Charles F Emery, Lening Zhang, Karin F Hoth, James Murphy, Barry Make and National Emphysema Treatment Trial Research Group

Journal of cardiopulmonary rehabilitation and prevention, Vol.31(6), pp.386-391

11/2011

DOI: 10.1097/HCR.0b013e3182343bc8

PMCID: PMC3221608

PMID: 22089885

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Abstract

This study compared visuomotor speed and cognitive flexibility in emphysema patients treated with either standard multidisciplinary medical therapy (MT) or lung volume reduction surgery (LVRS), followed over a 2-year period. MT patients (n = 544) and 542 LVRS patients completed the Trail Making Test (TMT) Parts A and B prior to randomization (baseline). Testing was repeated at 1 and 2 years. There were no differences on scores for TMT Parts A and B between the LVRS and MT groups at baseline or at years 1 and 2. No significant difference between MT and LVRS was noted in terms of overall change in TMT Parts A and B over 2 years. The MT group had a significant improvement on TMT Part A at each followup time compared with baseline (P < .03) but the LVRS group did not. Both the MT and LVRS groups had a significant decline in performance (increase in time to completion) on TMT Part B when comparing year 1 with baseline (P < .0001). Emphysema patients who received LVRS or MT as treatment performed similarly on measures of visuomotor speed and flexibility at baseline and 1- and 2-year followup. Both groups showed improvement on visuomotor speed during the first year yet overall cognitive flexibility declined. By the second year neither group had any significant change from baseline. These findings suggest that improvement on visuomotor speed and flexibility, observed in a previous 6-month study of LVRS subjects, was not sustained at 1- and 2-year followup.

Psychomotor Performance

Prospective Studies

Follow-Up Studies

Humans

Male

Pulmonary Emphysema - surgery

Treatment Outcome

Cognition

Pneumonectomy

Forced Expiratory Volume

Trail Making Test - statistics & numerical data

Female

Aged

Lung - surgery

Longitudinal Studies

Details

Title: Subtitle: Sequential cognitive skills in emphysema patients following lung volume reduction surgery: a 2-year longitudinal study
Creators: Elizabeth Kozora - National Jewish Health, Denver, CO 80206, USA. kozorae@njhealth.org
Charles F Emery
Lening Zhang
Karin F Hoth
James Murphy
Barry Make
National Emphysema Treatment Trial Research Group
Resource Type: Journal article
Publication Details: Journal of cardiopulmonary rehabilitation and prevention, Vol.31(6), pp.386-391
DOI: 10.1097/HCR.0b013e3182343bc8
PMID: 22089885
PMCID: PMC3221608
NLM abbreviation: J Cardiopulm Rehabil Prev
ISSN: 1932-7501
eISSN: 1932-751X
Publisher: United States
Grant note: M01 RR000051-44 / NCRR NIH HHS M01 RR000034 / NCRR NIH HHS M01-RR00034 / NCRR NIH HHS M01-RR00051 / NCRR NIH HHS R01- HL63761-01 / NHLBI NIH HHS M01 RR000051 / NCRR NIH HHS M01 RR000034-44 / NCRR NIH HHS R01 HL063761 / NHLBI NIH HHS UL1 RR025755 / NCRR NIH HHS R01 HL063761-01 / NHLBI NIH HHS
Language: English
Date published: 11/2011
Academic Unit: Psychiatry; Iowa Neuroscience Institute
Record Identifier: 9984003943202771

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