Journal article
Serial therapy-induced changes in tumor shape in cervical cancer and their impact on assessing tumor volume and treatment response
American journal of roentgenology (1976), Vol.187(1), pp.65-72
2006
DOI: 10.2214/AJR.05.0039
PMID: 16794157
Abstract
OBJECTIVE. The purpose of this study was to evaluate the patterns and distribution of tumor shape and its temporal change during radiation therapy (RT) in cervical cancer and the effect of tumor configuration changes on the correlation between region of interest (ROI)-based and diameter-based MRI tumor measurement.
MATERIALS AND METHODS. Serial MRI examinations (T1-weighted and T2-weighted images) were performed in 60 patients (age range, 29-75 years; mean, 53.3 years) with advanced cervical cancer (stages IB2-IVB/recurrent) who were treated with RT at four time points: start of RT, during RT (at 2-2.5 and at 4-5 weeks of RT), and post-RT. Tumor configuration was classified qualitatively into oval, lobulated, and complex based on MR film review. Two methods of tumor volume measurement were compared: ellipsoid computation of three orthogonal diameters (diameter based) and ROI volumetry by delineating the entire tumor volume on the MR workstation (ROI based). Temporal changes of tumor shape and the respective tumor volumes measured by the two methods were analyzed using linear regression analysis.
RESULTS. Most tumors (70%) had a non-oval (lobulated and complex) shape before RT and became increasingly irregular during and after RT: 84% at 2-2.5 weeks of RT (p = 0.037), 86% (p = 0.025) at 4-5 weeks, and 96% post-RT (p = 0.010), compared with 70% pre-RT. Diameter-based and ROI-based measurement correlated well before RT (r = 0.89) but not during RT (r = 0.68 at 2-2.5 weeks, r = 0.67 at 4-5 weeks of RT).
CONCLUSION. Most cervical cancers are not oval in shape pretherapy, and they become increasingly irregular during and after therapy because of nonconcentric tumor shrinkage. ROI-based volumetry, which can optimally measure irregular volumes, may provide better response assessment during treatment than diameter-based measurement.
Details
- Title: Subtitle
- Serial therapy-induced changes in tumor shape in cervical cancer and their impact on assessing tumor volume and treatment response
- Creators
- Nina A MAYR - Department of Radiation Medicine, Division of Radiation Dncology, Arthur G. James Hospital and Solove Research Institute, The Dhio State University, College of Medicine, 300 W 10th Ave., Rm. 080, Columbus, OH 43210, United StatesWilliam T. C YUH - Department of Radiology, The Ohio State University, Columbus, OH, United StatesJoel I SOROSKY - Department of Obstetrics and Gynecology, University of Connecticut, Hartford, CT, United StatesMichael V KNOPP - Department of Radiology, The Ohio State University, Columbus, OH, United StatesJohn M BUATTI - Department of Radiation Oncology, The University of Iowa College of Medicine, Iowa City, IA, United StatesToshiaki TAOKA - Magnetic Resonance Imaging Center, Department of Radiology, The University of Iowa, Iowa City, IA, United StatesJian Z WANG - Department of Radiation Medicine, Division of Radiation Dncology, Arthur G. James Hospital and Solove Research Institute, The Dhio State University, College of Medicine, 300 W 10th Ave., Rm. 080, Columbus, OH 43210, United StatesDee H WU - Department of Radiological Sciences, Oklahoma University Health Sciences Center, Oklahoma City, OK, United StatesJoseph F MONTEBELLO - Department of Radiation Medicine, Division of Radiation Dncology, Arthur G. James Hospital and Solove Research Institute, The Dhio State University, College of Medicine, 300 W 10th Ave., Rm. 080, Columbus, OH 43210, United StatesSanford L MEEKS - Department of Radiation Oncology, M. D. Anderson Cancer Center, Orlando, FL, United StatesArnold C PAULINO - Department of Radiation Oncology, Baylor College of Medicine, Houston, TX, United StatesVincent A MAGNOTTA - Magnetic Resonance Imaging Center, Department of Radiology, The University of Iowa, Iowa City, IA, United StatesMustafa ADLI - Department of Radiation Oncology, The University of Iowa College of Medicine, Iowa City, IA, United States
- Resource Type
- Journal article
- Publication Details
- American journal of roentgenology (1976), Vol.187(1), pp.65-72
- Publisher
- American Roentgen Ray Society; Leesburg, VA
- DOI
- 10.2214/AJR.05.0039
- PMID
- 16794157
- ISSN
- 0361-803X
- eISSN
- 1546-3141
- Language
- English
- Date published
- 2006
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Psychiatry; Iowa Neuroscience Institute; Radiation Oncology; Neurosurgery; Otolaryngology
- Record Identifier
- 9984040254602771
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