Journal article
Serious Adverse Events in Related Donors: A Report from the Related Donor Safe Study
Transplantation and cellular therapy, Vol.27(4), pp.352.e1-352.e5
04/2021
DOI: 10.1016/j.jtct.2021.01.009
PMCID: PMC8036235
PMID: 33836890
Abstract
The incidence and risk factors for severe adverse events (SAEs) in related donors (RD) of hematopoietic cell transplants is unknown. The Related Donor Safe study is a prospective observational cohort of 1680 RDs and represents an opportunity to examine characteristics of SAEs in RDs. In this cohort, we found that SAEs were reported in a total 12 (0.71%) RDs. Of these, 5 SAEs occurred in bone marrow donors (5/404, 1.24%), and 7 (7/1276, 0.55%) were in donors of peripheral blood stem cells. All of the SAEs were considered to be related (definite, probable, or possible) to the donation process. There were no donor fatalities. Of the 12 RDs who experienced an SAE, 10 were either overweight or obese. Five of the 12 RDs had predonation medical conditions that would have resulted in either possible or definite ineligibility for donation were they being assessed as unrelated donors. These SAE data will be useful in the counseling of prospective RDs before planned donation and may be helpful in identifying donors who should be considered medically unsuitable for donation.
Details
- Title: Subtitle
- Serious Adverse Events in Related Donors: A Report from the Related Donor Safe Study
- Creators
- Matthew D. Seftel - University of British ColumbiaPintip Chitphakdithai - National Marrow Donor ProgramJohn P. Miller - National Marrow Donor ProgramHati Kobusingye - National Marrow Donor ProgramBrent R. Logan - Medical College of WisconsinMichael Linenberger - Fred Hutch Cancer CenterAndrew S. Artz - University of ChicagoAnn E. Haight - Children's Healthcare of AtlantaDavid A. Jacobsohn - Children's NationalMark R. Litzow - Mayo ClinicMargarida Magalhaes-Silverman - University of IowaGeorge B. Selby - University of Oklahoma Health Sciences CenterMadhuri Vusirikala - The University of Texas Southwestern Medical CenterMary M. Horowitz - Medical College of WisconsinGalen E. Switzer - University of PittsburghDennis L. Confer - National Marrow Donor ProgramBronwen E. Shaw - Medical College of WisconsinMichael A. Pulsipher - Children's Hospital of Los Angeles
- Resource Type
- Journal article
- Publication Details
- Transplantation and cellular therapy, Vol.27(4), pp.352.e1-352.e5
- DOI
- 10.1016/j.jtct.2021.01.009
- PMID
- 33836890
- PMCID
- PMC8036235
- NLM abbreviation
- Transplant Cell Ther
- ISSN
- 2666-6367
- eISSN
- 2666-6367
- Publisher
- Elsevier Inc
- Grant note
- DOI: 10.13039/100000102, name: Health Resources and Services Administration; DOI: 10.13039/100000054, name: National Cancer Institute; DOI: 10.13039/100000006, name: Office of Naval Research; DOI: 10.13039/100000050, name: National Heart, Lung, and Blood Institute; DOI: 10.13039/100000060, name: National Institute of Allergy and Infectious Diseases
- Language
- English
- Date published
- 04/2021
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
- Record Identifier
- 9984360039702771
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