Journal article
Seroepidemiology of Hepatitis B in the Democratic Republic of the Congo
The American journal of tropical medicine and hygiene, Vol.101(1), pp.226-229
01/01/2019
DOI: 10.4269/ajtmh.18-0883
PMCID: PMC6609197
PMID: 31074406
Abstract
Hepatitis B virus (HBV) is endemic throughout Africa, but its prevalence in the Democratic Republic of the Congo (DRC) is incompletely understood. We used dried blood spot (DBS) samples from the 2013 to 2014 Demographic and Health Survey in the DRC to measure the prevalence of HBV using the Abbott ARCHITECT HBV surface antigen (HBsAg) qualitative assay. We then attempted to sequence and genotype HBsAg-positive samples. The weighted national prevalence of HBV was 3.3% (95% CI: 1.8-4.7%), with a prevalence of 2.2% (95% CI: 0.3-4.1%) among children. Hepatitis B virus cases occurred countrywide and across age strata. Genotype E predominated (60%), and we found a unique cluster of genotype A isolates (30%). In conclusion, DBS-based HBsAg testing from a nationally representative survey found that HBV is common and widely distributed among Congolese adults and children. The distribution of cases across ages suggests ongoing transmission and underscores the need for additional interventions to prevent HBV infection.
Details
- Title: Subtitle
- Seroepidemiology of Hepatitis B in the Democratic Republic of the Congo
- Creators
- Peyton Thompson - University of North Carolina at Chapel HillJonathan B. Parr - University of North Carolina at Chapel HillVera Holzmayer - Abbott Laboratories, Abbott Park, Illinois.Margaret Carrel - University of IowaAntoinette Tshefu - University of KinshasaKashamuka Mwandagalirwa - University of KinshasaJeremie Muwonga - National AIDS Control Program, Kinshasa, Democratic Republic of the Congo.Placide O. Welo - National AIDS Control Program, Kinshasa, Democratic Republic of the Congo.Franck Fwamba - National AIDS Control Program, Kinshasa, Democratic Republic of the Congo.Mary Kuhns - Abbott Laboratories, Abbott Park, Illinois.Ravi Jhaveri - Northwestern UniversitySteven R. Meshnick - University of North Carolina at Chapel HillGavin Cloherty - Abbott Laboratories, Abbott Park, Illinois.
- Resource Type
- Journal article
- Publication Details
- The American journal of tropical medicine and hygiene, Vol.101(1), pp.226-229
- DOI
- 10.4269/ajtmh.18-0883
- PMID
- 31074406
- PMCID
- PMC6609197
- NLM abbreviation
- Am J Trop Med Hyg
- ISSN
- 0002-9637
- eISSN
- 1476-1645
- Publisher
- Amer Soc Trop Med & Hygiene
- Number of pages
- 4
- Grant note
- Doris Duke Charitable Foundation; Doris Duke Charitable Foundation (DDCF) Abbott Laboratories 5T32AI007151; 5R01AI107949 / National Institute of Allergy and Infectious Diseases; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID)
- Language
- English
- Date published
- 01/01/2019
- Academic Unit
- Epidemiology; Interdisciplinary Programs; Geographical and Sustainability Sciences; Internal Medicine
- Record Identifier
- 9984259635802771
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