Seroepidemiology of Trypanosoma cruzi, Etiologic Agent of Chagas' Disease, in US Blood Donors

David A. Leiby; Elizabeth J. Read; Bruce A. Lenes; A. Jeffrey Yund; Robert J. Stumpf; Louis V. Kirchhoff; Roger Y. Dodd

doi:10.1086/516534

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Seroepidemiology of Trypanosoma cruzi, Etiologic Agent of Chagas' Disease, in US Blood Donors

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Seroepidemiology of Trypanosoma cruzi, Etiologic Agent of Chagas' Disease, in US Blood Donors

David A. Leiby, Elizabeth J. Read, Bruce A. Lenes, A. Jeffrey Yund, Robert J. Stumpf, Louis V. Kirchhoff and Roger Y. Dodd

The Journal of infectious diseases, Vol.176(4), pp.1047-1052

10/1997

DOI: 10.1086/516534

PMID: 9333165

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Abstract

A comprehensive seroepidemiologic study was conducted in two Red Cross regions (Los Angeles and Miami) to determine the prevalence of Trypanosoma cruzi antibodies in at-risk blood donors, to identify additional risk factors, and to assess the likelihood of transmitting T. cruzi by transfusion. At-risk and control donors were stratified by a broad risk question, tested for T. cruzi antibodies, and if confirmed as seropositive, enrolled in case-control and lookback investigations. A total of 299,398 donors were queried; 23,978 at-risk and 25,587 control donations were tested, and T. cruzi antibodies were confirmed in 34 donors (33 and 1, respectively). Seropositive donors shared one risk factor; birth/extensive time in a T. cruzi-endemic area. Lookback studies identified 11 recipients, all negative for T. cruzi antibodies. Screening strategies that use a question are unlikely to identify all seropositive donors. The lack of definitive data on the risk of transmission by transfusion indicates additional studies of donors and recipients are needed.

Details

Title: Subtitle: Seroepidemiology of Trypanosoma cruzi, Etiologic Agent of Chagas' Disease, in US Blood Donors
Creators: David A. Leiby - American Red Cross
Elizabeth J. Read - Uniformed Services University of the Health Sciences
Bruce A. Lenes - Uniformed Services University of the Health Sciences
A. Jeffrey Yund - Uniformed Services University of the Health Sciences
Robert J. Stumpf - Uniformed Services University of the Health Sciences
Louis V. Kirchhoff - Uniformed Services University of the Health Sciences
Roger Y. Dodd - Uniformed Services University of the Health Sciences
Resource Type: Journal article
Publication Details: The Journal of infectious diseases, Vol.176(4), pp.1047-1052
DOI: 10.1086/516534
PMID: 9333165
NLM abbreviation: J Infect Dis
ISSN: 0022-1899
eISSN: 1537-6613
Publisher: The University of Chicago Press
Language: English
Date published: 10/1997
Academic Unit: Psychiatry; Infectious Diseases; Epidemiology; Internal Medicine
Record Identifier: 9984280872802771

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